Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50026108
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271628(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271629(N-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-4-yl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271631(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin E(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271627(N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-y...)
Affinity DataKi:  2nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271705((4R)-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271626(N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271630(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271627(N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-y...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271703(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271862(N1-((1S,2S)-1-((S)-4-(2-methoxybenzyl)-3-oxopipera...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227337(N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-[(2R,4S)-4-ET...)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271632(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271810(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271768(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271861(N1-((1S,2S)-1-((S)-4-(cyclopropylmethyl)-3-oxopipe...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271811(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271860(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((S...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271770(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227345(N'-[(1S,2R)-2-[(2R,4S)-4-benzylpiperidin-2-yl]-1-(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271767((4R)-4-benzyl-N-((1S,2S)-1-((S)-4-benzyl-3-oxopipe...)
Affinity DataIC50: 16nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271863(N1-((1S,2S)-1-((R)-4-(2-cyanobenzyl)piperazin-2-yl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271626(N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3...)
Affinity DataIC50: 22nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271769(1-benzyl-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin...)
Affinity DataIC50: 22nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271812(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271864(N1-((1S,2S)-1-((R)-4-(2-chlorobenzyl)piperazin-2-y...)
Affinity DataIC50: 27nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin E(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271626(N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3...)
Affinity DataKi:  30nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271627(N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-y...)
Affinity DataKi:  32nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271859(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((S...)
Affinity DataIC50: 44nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271626(N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3...)
Affinity DataKi:  47nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271627(N'-[(1S,2S)-2-[(4S)-1-benzyl-5-oxoimidazolidin-4-y...)
Affinity DataIC50: 51nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271630(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 57nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271628(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 75nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271766((4R)-N-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-...)
Affinity DataIC50: 88nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227337(N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-[(2R,4S)-4-ET...)
Affinity DataIC50: 106nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227347(N1-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R...)
Affinity DataIC50: 130nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271631(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271704(N-((1S,2S)-1-((S)-1-benzyl-5-oxoimidazolidin-4-yl)...)
Affinity DataIC50: 140nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271858(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-((S)-4-ethyl-...)
Affinity DataIC50: 175nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271703(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271814(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((S...)
Affinity DataIC50: 235nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271705((4R)-N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-y...)
Affinity DataIC50: 240nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227347(N1-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R...)
Affinity DataIC50: 240nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271813(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((S...)
Affinity DataIC50: 264nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271626(N1-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271865(N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((R...)
Affinity DataIC50: 345nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271632(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 510nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227345(N'-[(1S,2R)-2-[(2R,4S)-4-benzylpiperidin-2-yl]-1-(...)
Affinity DataIC50: 522nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271768(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 530nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271862(N1-((1S,2S)-1-((S)-4-(2-methoxybenzyl)-3-oxopipera...)
Affinity DataIC50: 550nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271810(N-((1S,2S)-1-((S)-4-benzyl-3-oxopiperazin-2-yl)-3-...)
Affinity DataIC50: 620nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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