Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50026469
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251950((S)-4-(2,5-difluorophenyl)-N-methyl-N-(1-methylpip...)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252100((2S)-4-(2,5-difluorophenyl)-N-(1-(2-fluoroethyl)pi...)
Affinity DataIC50:  1.38E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252044((2S)-4-(2,5-Difluorophenyl)-2-(hydroxymethyl)-N-me...)
Affinity DataIC50:  1.46E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252101((2S)-N-(1-cyclopropylpiperidin-4-yl)-4-(2,5-difluo...)
Affinity DataIC50:  1.52E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220328((S)-2-((R)-3-amino-4,4-difluorobutyl)-4-(2,5-diflu...)
Affinity DataIC50:  1.59E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252045((S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N-met...)
Affinity DataIC50:  1.92E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50:  2.05E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252150((S)-4-(2,5-difluorophenyl)-N-((3S,4S)-3-fluoro-1-m...)
Affinity DataIC50:  3.69E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCentromere-associated protein E(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human CENP-EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin-like protein KIF23(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human MKLP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin-like protein KIF3A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human Kif3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin-like protein KIF1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human Kif1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin-1 heavy chain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human uKHCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin heavy chain isoform 5A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human nKHCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin-like protein KIF14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human Kif14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKinesin-like protein KIF2C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human MCAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed