Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50026612
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 300nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL after differentiation assessed as effect on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263196(N-(5-Aminomethyl-4,6-dimethyl-1-octylindolin-7-yl)...)
Affinity DataIC50: 330nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263150(N-(4,6-dimethyl-1-octylindolin-7-yl)pivalamide | N...)
Affinity DataIC50: 640nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50069900(CHEMBL101309 | [2-(2,4,6-Triisopropyl-phenyl)-acet...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | [7-(2,2-Dimethylprop...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263193(3-[4,6-Dimethyl-7-(2,2-dimethylpropanamido)-1-octy...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263194(10-[7-(2,2-Dimethylpropanamido)-4,6-dimethylindoli...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263195(4-(4,6-Dimethyl-1-octylindolin-7-yl)carbamoyl-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263241(N-[4,6-Dimethyl-1-octyl-5-(1H-tetrazol-5-ylmethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed