Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50026694
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-methyl-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-methyl-...)
Affinity DataKi:  2.03nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102006(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM25870(CITALOPRAM HYDROBROMIDE | [3H]Escitalopram | Escit...)
Affinity DataKi:  4.38nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102010(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  4.51nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262513(cis-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinol...)
Affinity DataKi:  6.16nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM25870(CITALOPRAM HYDROBROMIDE | [3H]Escitalopram | Escit...)
Affinity DataKi:  32.8nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102008(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  73.7nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102019(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  90.7nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102008(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  96.7nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102006(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  165nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102019(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  184nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102010(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  189nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102008(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  267nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102019(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  286nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102019(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  309nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  327nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  343nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262513(cis-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinol...)
Affinity DataKi:  366nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102006(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102010(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  424nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102008(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  462nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102008(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  518nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262513(cis-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinol...)
Affinity DataKi:  772nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262513(cis-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinol...)
Affinity DataKi:  914nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102010(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102006(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  1.02E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102010(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  1.43E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi:  2.31E+3nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102019(3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]...)
Affinity DataKi:  2.53E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262514(trans-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquin...)
Affinity DataKi: >2.86E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50262513(cis-3-(4-(6-(3-fluoropropoxy)-3,4-dihydroisoquinol...)
Affinity DataKi:  5.67E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Institut FüR InterdisziplinäRe Isotopenforschung

Curated by ChEMBL
LigandPNGBDBM50102006(3-[4-(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-c...)
Affinity DataKi:  1.31E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed