Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50026709 Sort by
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273004(5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydr...)
Affinity DataEC50:  9.50E+6nMAssay Description:Agonist activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  2.80E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  1.82E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  2.30E+6nMAssay Description:Agonist activity at rat recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  1.28E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-4-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  1.37E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-5-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at rat recombinant GABAA alpha-6-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [3H]Muscimol from GABAAalpha6 receptor in Sprague-Dawley rat brain cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273003([5-(2-Amino-ethyl)-3H-[1,3,4]oxadiazol-2-one Hydro...)
Affinity DataIC50: 7.40E+3nMAssay Description:Displacement of [3H]Muscimol from GABAAalpha6 receptor in Sprague-Dawley rat brain cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273043(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-thione Hydroch...)
Affinity DataIC50: 4.90E+4nMAssay Description:Displacement of [3H]Muscimol from GABAAalpha6 receptor in Sprague-Dawley rat brain cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273004(5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydr...)
Affinity DataIC50: 5.90E+4nMAssay Description:Agonist activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes as inhibition of GABA-induced current at -60 mV b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273004(5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydr...)
Affinity DataIC50: 6.60E+4nMAssay Description:Displacement of [3H]Muscimol from GABAAalpha6 receptor in Sprague-Dawley rat brain cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273110(4-(5-Methyl-[1,3,4]oxadiazol-2-yl)-piperidine Hydr...)
Affinity DataIC50: 7.60E+4nMAssay Description:Displacement of [3H]Muscimol from GABAAalpha6 receptor in Sprague-Dawley rat brain cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273001(5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-one Hydroch...)
Affinity DataIC50: 1.23E+5nMAssay Description:Displacement of [3H]Muscimol from GABAAalpha6 receptor in Sprague-Dawley rat brain cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed