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Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 2954
TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26333(1-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)ph...)
Affinity DataIC50:  4nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  9nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26322(1-(3-methylphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  9nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26330(1-(3-chloro-4-fluorophenyl)-3-[5-(2-{thieno[3,2-d]...)
Affinity DataIC50:  11nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26329(1-(3,4-dichlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrim...)
Affinity DataIC50:  13nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26315(3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  14nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26325(1-(3-fluorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  18nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26331(1-1H-indol-7-yl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-...)
Affinity DataIC50:  19nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26315(3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  22nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26333(1-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)ph...)
Affinity DataIC50:  22nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26325(1-(3-fluorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  23nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26331(1-1H-indol-7-yl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-...)
Affinity DataIC50:  30nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  31nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26327(1-(4-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  39nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26324(1-(3-ethynylphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidi...)
Affinity DataIC50:  41nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26323(1-(3-methoxyphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidi...)
Affinity DataIC50:  50nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26330(1-(3-chloro-4-fluorophenyl)-3-[5-(2-{thieno[3,2-d]...)
Affinity DataIC50:  51nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26320(1-phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino...)
Affinity DataIC50:  52nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26334(1-{3-[2-(azetidin-1-yl)ethyl]phenyl}-3-[5-(2-{thie...)
Affinity DataIC50:  53nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26322(1-(3-methylphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  54nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26332(1-cyclohexyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-yla...)
Affinity DataIC50:  61nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26329(1-(3,4-dichlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrim...)
Affinity DataIC50:  96nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26320(1-phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino...)
Affinity DataIC50:  120nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26334(1-{3-[2-(azetidin-1-yl)ethyl]phenyl}-3-[5-(2-{thie...)
Affinity DataIC50:  120nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26314(3-[1-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  250nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26332(1-cyclohexyl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-yla...)
Affinity DataIC50:  270nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26328(1-(2-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  280nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26319(2-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  442nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Sunesis Pharmaceuticals

LigandPNGBDBM26318(N-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  580nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26313(3-[1-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  1.20E+3nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26311(3-[4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)ph...)
Affinity DataIC50:  1.20E+3nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26317(N-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  2.50E+3nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26309(CHEMBL459888 | N-[4-(2-{thieno[3,2-d]pyrimidin-4-y...)
Affinity DataIC50:  3.20E+3nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26319(2-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  4.90E+3nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26321(1-methyl-1-phenyl-3-[5-(2-{thieno[3,2-d]pyrimidin-...)
Affinity DataIC50:  7.20E+3nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26318(N-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26310(4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-N-[3...)
Affinity DataIC50: >2.00E+4nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26312(3-[3-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)ph...)
Affinity DataIC50: >2.00E+4nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Mouse)
Sunesis Pharmaceuticals

LigandPNGBDBM26316(3-[4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50: >2.00E+4nMpH: 7.2 T: 21°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed