Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 2783
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24615BDBM24615(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24616BDBM24616(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(pyri...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24601BDBM24601(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24617BDBM24617(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24606BDBM24606(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24608BDBM24608(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24609BDBM24609(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24611BDBM24611(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24614BDBM24614(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...)
Affinity DataKi: <4nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24607BDBM24607(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...)
Affinity DataKi:  5nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24610BDBM24610(1-[5,7-bis(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-...)
Affinity DataKi:  6nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24609BDBM24609(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24616BDBM24616(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(pyri...)
Affinity DataKi:  7nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24606BDBM24606(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...)
Affinity DataKi:  8nM ΔG°:  -47.0kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 282BDBM282(Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24615BDBM24615(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24601BDBM24601(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24617BDBM24617(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...)
Affinity DataKi:  11nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24615BDBM24615(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...)
Affinity DataKi:  12nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24616BDBM24616(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(pyri...)
Affinity DataKi:  12nM ΔG°:  -46.0kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24609BDBM24609(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...)
Affinity DataKi:  14nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24611BDBM24611(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...)
Affinity DataKi:  14nM ΔG°:  -45.6kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 282BDBM282(Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6...)
Affinity DataKi:  14nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24608BDBM24608(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...)
Affinity DataKi:  15nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24613BDBM24613(3-ethyl-1-[6-methoxy-5-(2-methoxypyrimidin-5-yl)-1...)
Affinity DataKi:  15nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24614BDBM24614(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...)
Affinity DataKi:  16nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24610BDBM24610(1-[5,7-bis(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-...)
Affinity DataKi:  17nM ΔG°:  -45.1kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24612BDBM24612(1-[7-(benzyloxy)-5-(pyridin-3-yl)-1H-1,3-benzodiaz...)
Affinity DataKi:  18nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24600BDBM24600(3-ethyl-1-[5-(pyrimidin-5-yl)-1H-1,3-benzodiazol-2...)
Affinity DataKi:  20nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24611BDBM24611(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...)
Affinity DataKi:  23nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24617BDBM24617(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...)
Affinity DataKi:  23nM ΔG°:  -44.3kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24607BDBM24607(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...)
Affinity DataKi:  26nM ΔG°:  -44.0kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24602BDBM24602(3-ethyl-1-[6-fluoro-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  33nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24612BDBM24612(1-[7-(benzyloxy)-5-(pyridin-3-yl)-1H-1,3-benzodiaz...)
Affinity DataKi:  35nM ΔG°:  -43.3kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24606BDBM24606(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...)
Affinity DataKi:  35nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24602BDBM24602(3-ethyl-1-[6-fluoro-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  38nM ΔG°:  -43.1kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24613BDBM24613(3-ethyl-1-[6-methoxy-5-(2-methoxypyrimidin-5-yl)-1...)
Affinity DataKi:  44nM ΔG°:  -42.7kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24608BDBM24608(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...)
Affinity DataKi:  46nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24600BDBM24600(3-ethyl-1-[5-(pyrimidin-5-yl)-1H-1,3-benzodiazol-2...)
Affinity DataKi:  49nM ΔG°:  -42.4kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24614BDBM24614(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...)
Affinity DataKi:  58nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24603BDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  61nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24601BDBM24601(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...)
Affinity DataKi:  78nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24605BDBM24605(3-ethyl-1-[6-(piperidin-1-yl)-5-(pyridin-3-yl)-1H-...)
Affinity DataKi:  81nM ΔG°:  -41.2kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24598BDBM24598(3-ethyl-1-[5-(pyridin-3-yl)-1H-1,3-benzodiazol-2-y...)
Affinity DataKi:  81nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24603BDBM24603(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  85nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 282BDBM282(Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6...)
Affinity DataKi:  110nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24605BDBM24605(3-ethyl-1-[6-(piperidin-1-yl)-5-(pyridin-3-yl)-1H-...)
Affinity DataKi:  120nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24604BDBM24604(3-ethyl-1-[6-methoxy-5-(pyridin-3-yl)-1H-1,3-benzo...)
Affinity DataKi:  130nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24598BDBM24598(3-ethyl-1-[5-(pyridin-3-yl)-1H-1,3-benzodiazol-2-y...)
Affinity DataKi:  130nM ΔG°:  -40.0kJ/molepH: 7.5 T: 2°CAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24607BDBM24607(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...)
Affinity DataKi:  150nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
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