Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 3065
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Kudos Pharmaceuticals

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1nMAssay Description:A FlashPlate scintillation proximity assay has been used to identify inhibitors of PARP-2. PARP-2 protein (recombinant) was bound down by a PARP-2 sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27567(4-({3-[(4-cyclopentanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27546(4-[(3-{[4-(pyrimidin-2-yl)piperazin-1-yl]carbonyl}...)
Affinity DataIC50:  2nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27570(4-[(4-fluoro-3-{[4-(oxolan-3-ylcarbonyl)piperazin-...)
Affinity DataIC50:  2nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27545(4-[(4-fluoro-3-{[4-(pyridin-2-yl)piperazin-1-yl]ca...)
Affinity DataIC50:  2nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27542(4-(3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H...)
Affinity DataIC50:  2nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27547(4-[(4-fluoro-3-{[4-(pyrimidin-2-yl)piperazin-1-yl]...)
Affinity DataIC50:  3nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27569(4-[(4-fluoro-3-{[4-(oxolan-2-ylcarbonyl)piperazin-...)
Affinity DataIC50:  3nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27563(4-[(3-{[4-(cyclopropylmethyl)piperazin-1-yl]carbon...)
Affinity DataIC50:  4nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27543(4-{[4-fluoro-3-(piperazin-1-ylcarbonyl)phenyl]meth...)
Affinity DataIC50:  5nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27562(4-({3-[(4-butylpiperazin-1-yl)carbonyl]-4-fluoroph...)
Affinity DataIC50:  5nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27565(4-({4-fluoro-3-[(4-propanoylpiperazin-1-yl)carbony...)
Affinity DataIC50:  5nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27553(4-({4-fluoro-3-[(4-phenylpiperazin-1-yl)carbonyl]p...)
Affinity DataIC50:  5nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27551(4-[(4-fluoro-3-{[4-(morpholin-4-ylcarbonyl)piperaz...)
Affinity DataIC50:  6nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27555(4-({3-[(4-benzoylpiperazin-1-yl)carbonyl]-4-fluoro...)
Affinity DataIC50:  6nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27560(4-({3-[(4-ethylpiperazin-1-yl)carbonyl]-4-fluoroph...)
Affinity DataIC50:  6nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27564(4-({3-[(4-acetylpiperazin-1-yl)carbonyl]-4-fluorop...)
Affinity DataIC50:  6nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27561(4-({4-fluoro-3-[(4-propylpiperazin-1-yl)carbonyl]p...)
Affinity DataIC50:  6nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27535(4-[(4-fluoro-3-{[4-(2-hydroxyethyl)-1,4-diazepan-1...)
Affinity DataIC50:  7nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataIC50:  7nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27550(4-[(3-{[4-(morpholin-4-ylcarbonyl)piperazin-1-yl]c...)
Affinity DataIC50:  8nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27549(4-[(3-{[4-(ethanesulfonyl)piperazin-1-yl]carbonyl}...)
Affinity DataIC50:  8nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27539(4-[(4-fluoro-3-{[4-(morpholin-4-ylcarbonyl)-1,4-di...)
Affinity DataIC50:  8nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27544(4-[(3-{[4-(pyridin-2-yl)piperazin-1-yl]carbonyl}ph...)
Affinity DataIC50:  10nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27554(4-({3-[(4-benzoylpiperazin-1-yl)carbonyl]phenyl}me...)
Affinity DataIC50:  11nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27557(4-[(4-fluoro-3-{[4-(2-hydroxyethyl)piperazin-1-yl]...)
Affinity DataIC50:  12nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27540(4-({3-[(4-acetyl-1,4-diazepan-1-yl)carbonyl]-4-flu...)
Affinity DataIC50:  12nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27548(4-[(3-{[4-(ethanesulfonyl)piperazin-1-yl]carbonyl}...)
Affinity DataIC50:  12nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27541(4-({3-[(4-cyclopropanecarbonyl-1,4-diazepan-1-yl)c...)
Affinity DataIC50:  12nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27559(4-({4-fluoro-3-[(4-methylpiperazin-1-yl)carbonyl]p...)
Affinity DataIC50:  13nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27568(4-({3-[(4-cyclohexanecarbonylpiperazin-1-yl)carbon...)
Affinity DataIC50:  15nMAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27536(4-({3-[(4-benzyl-1,4-diazepan-1-yl)carbonyl]phenyl...)
Affinity DataIC50:  18nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27534(4-[(3-{[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]carbo...)
Affinity DataIC50:  18nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27538(4-[(3-{[4-(morpholin-4-ylcarbonyl)-1,4-diazepan-1-...)
Affinity DataIC50:  20nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27537(4-[(3-{[4-(ethanesulfonyl)-1,4-diazepan-1-yl]carbo...)
Affinity DataIC50:  23nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27556(4-[(3-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}...)
Affinity DataIC50:  39nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27552(4-({3-[(4-phenylpiperazin-1-yl)carbonyl]phenyl}met...)
Affinity DataIC50:  51nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27558(4-({3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}met...)
Affinity DataIC50:  88nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1.50E+3nMAssay Description:An AlphaScreen (Perkin-Elmer) assay was developed in which His-tagged recombinant TANK-1 protein was incubated with biotinylated NAD+ in a 384-well P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)