Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50027265
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50263028(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7657(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50025069(CHEMBL485425)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50025068(CHEMBL484555)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7672(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274698(4-(4-(1-ethyl-2-methyl-1H-imidazol-5-yl)pyrimidin-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetG1/S-specific cyclin-E1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Cyclin E/CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274662(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274661(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274625(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(pr...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7674(CHEMBL484571 | Imidazo[1,2-b]pyridazine deriv. 2d ...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274626(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM7659(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)
Affinity DataIC50: <12nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274806(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-((t...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274805(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(2-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274699(4-(4-(1-isobutyl-2-methyl-1H-imidazol-5-yl)pyrimid...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetG2/mitotic-specific cyclin-B1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Cyclin B1/CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274746(CHEMBL457979 | N-(4-(benzylsulfonyl)phenyl)-4-(1-i...)
Affinity DataIC50:  19nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-T1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Cyclin T/CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetG1/S-specific cyclin-D3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Cyclin D3/CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274745(4-(1-ethyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274663(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274808(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(3-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274807(CHEMBL457887 | N-(4-(3-(dimethylamino)propylsulfon...)
Affinity DataIC50:  36nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  45nMAssay Description:Inhibition of Cyclin A/CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274743(CHEMBL458547 | N-(2-methoxyethyl)-4-(4-(1,2,4-trim...)
Affinity DataIC50:  68nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274700(4-(4-(1-cyclopropyl-2-methyl-1H-imidazol-5-yl)pyri...)
Affinity DataIC50:  83nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274807(CHEMBL457887 | N-(4-(3-(dimethylamino)propylsulfon...)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50263028(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274808(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(3-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274744(4-(1,2-dimethyl-1H-imidazol-5-yl)-N-(4-(3-(dimethy...)
Affinity DataIC50:  295nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274664(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50246253(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)
Affinity DataIC50:  450nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274805(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(2-...)
Affinity DataIC50:  490nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274806(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-((t...)
Affinity DataIC50:  530nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274698(4-(4-(1-ethyl-2-methyl-1H-imidazol-5-yl)pyrimidin-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274746(CHEMBL457979 | N-(4-(benzylsulfonyl)phenyl)-4-(1-i...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274661(4-(4-(1,2-dimethyl-1H-imidazol-5-yl)pyrimidin-2-yl...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274743(CHEMBL458547 | N-(2-methoxyethyl)-4-(4-(1,2,4-trim...)
Affinity DataIC50: >8.60E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50274700(4-(4-(1-cyclopropyl-2-methyl-1H-imidazol-5-yl)pyri...)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed