Compile Data Set for Download or QSAR
maximum 50k data
Found 36 Enz. Inhib. hit(s) with all data for entry = 50027605
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246459(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246460(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246458(4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-be...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245868(4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)benzo[...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246455(2-(3,4-dihydro-2H-chromen-3-yl)-6-(pyridin-4-yl)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245871(4-(2-(6-fluoro-3,4-dihydro-2H-chromen-3-yl)-3H-ben...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245916(CHEMBL462194 | methyl 3-(6-(2-aminopyrimidin-4-yl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246455(2-(3,4-dihydro-2H-chromen-3-yl)-6-(pyridin-4-yl)-1...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246456(4-(2-(3,4-dihydro-2H-chromen-3-yl)-3H-benzo[d]imid...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246412(2-(3,4-dihydro-2H-chromen-3-yl)-6-(5-methyl-1H-pyr...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246454(2-(3,4-dihydro-2H-chromen-3-yl)-6-(5-methyl-1H-pyr...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245914(4-(2-(6-fluoro-3,4-dihydro-2H-chromen-3-yl)benzo[d...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246410(2-(3,4-dihydro-2H-chromen-3-yl)-6-(1H-pyrazol-4-yl...)
Affinity DataIC50:  21nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246460(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50:  23nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245917(CHEMBL518665 | methyl 3-(6-(2-aminopyrimidin-4-yl)...)
Affinity DataIC50:  24nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246411(2-(3,4-dihydro-2H-chromen-3-yl)-6-(1H-pyrazol-4-yl...)
Affinity DataIC50:  27nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246457(4-(2-(3,4-dihydro-2H-chromen-3-yl)benzo[d]oxazol-6...)
Affinity DataIC50:  27nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245914(4-(2-(6-fluoro-3,4-dihydro-2H-chromen-3-yl)benzo[d...)
Affinity DataIC50:  28nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245868(4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)benzo[...)
Affinity DataIC50:  46nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246456(4-(2-(3,4-dihydro-2H-chromen-3-yl)-3H-benzo[d]imid...)
Affinity DataIC50:  66nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245915(4-(2-(6-methyl-3,4-dihydro-2H-chromen-3-yl)benzo[d...)
Affinity DataIC50:  78nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246411(2-(3,4-dihydro-2H-chromen-3-yl)-6-(1H-pyrazol-4-yl...)
Affinity DataIC50:  86nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246458(4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-be...)
Affinity DataIC50:  99nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246459(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50:  212nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245916(CHEMBL462194 | methyl 3-(6-(2-aminopyrimidin-4-yl)...)
Affinity DataIC50:  271nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245870(4-(2-(6-isopropoxy-3,4-dihydro-2H-chromen-3-yl)ben...)
Affinity DataIC50:  294nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245869(4-(2-(6-isopropoxy-3,4-dihydro-2H-chromen-3-yl)-3H...)
Affinity DataIC50:  296nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246410(2-(3,4-dihydro-2H-chromen-3-yl)-6-(1H-pyrazol-4-yl...)
Affinity DataIC50:  330nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246454(2-(3,4-dihydro-2H-chromen-3-yl)-6-(5-methyl-1H-pyr...)
Affinity DataIC50:  533nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50:  1.41E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50:  1.68E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed