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Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50038739
LigandPNGBDBM50092131(1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50061977(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50048403(1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...)
Affinity DataKi:  140nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50377980(CHEMBL558625)
Affinity DataKi:  4.40E+3nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM92478(Atracurium besylate | CHEMBL1360)
Affinity DataKi:  5.90E+3nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataKi:  9.20E+3nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50377979(PENUCURONIUM)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275157(CHEMBL453730 | N-cyclohexyl-2-(3,5-dimethyl-1H-pyr...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275184(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275183(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50377980(CHEMBL558625)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275131(2-(1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataKd:  1.40E+4nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275130((1H-Benzoimidazol-2-yl)indan-1-ylamine | CHEMBL458...)
Affinity DataKd:  790nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275129((1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydronaphthal...)
Affinity DataKd:  130nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275128((1H-Benzoimidazol-2-yl)-(6,7,8,9-tetrahydro-5H-ben...)
Affinity DataKd:  590nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  47nMAssay Description:Inhibition of human SK2 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275126((1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydronaphtha...)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275125((1H-Benzoimidazol-2-yl)-(2-methyl-1,2,3,4-tetrahyd...)
Affinity DataKd:  170nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275092((1H-Benzoimidazol-2-yl)-(4-methyl-1,2,3,4-tetrahyd...)
Affinity DataKd:  32nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275091((1H-Benzoimidazol-2-yl)-(8-chloro-1,2,3,4-tetrahyd...)
Affinity DataKd:  27nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275053((1H-Benzoimidazol-2-yl)-(7-chloro-1,2,3,4-tetrahyd...)
Affinity DataKd:  17nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275052((1H-Benzoimidazol-2-yl)-(6-chloro-1,2,3,4-tetrahyd...)
Affinity DataKd:  120nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275051((1H-Benzoimidazol-2-yl)-(5-chloro-1,2,3,4-tetrahyd...)
Affinity DataKd:  44nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275050((1H-Benzoimidazol-2-yl)-(7-fluoro-1,2,3,4-tetrahyd...)
Affinity DataKd:  34nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275049((1H-Benzoimidazol-2-yl)-(7-bromo-1,2,3,4-tetrahydr...)
Affinity DataKd:  11nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  9.10nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275089((1H-Benzoimidazol-2-yl)-(7-methyl-1,2,3,4-tetrahyd...)
Affinity DataKd:  20nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275088((1H-Benzoimidazol-2-yl)-(5,7-dimethyl-1,2,3,4-tetr...)
Affinity DataKd:  33nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275087((1H-Benzoimidazol-2-yl)-(7-methoxy-1,2,3,4-tetrahy...)
Affinity DataKd:  61nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275054((1H-Benzoimidazol-2-yl)chroman-4-ylamine | CHEMBL5...)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275207((1H-Benzoimidazol-2-yl)thiochroman-4-yl-amine | CH...)
Affinity DataKd:  130nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275208((1H-Benzoimidazol-2-yl)-(5,6,7,8-tetrahydroisoquin...)
Affinity DataKd:  6.50E+3nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275209((1H-Benzoimidazol-2-yl)-(4,5,6,7-tetrahydrobenzo[b...)
Affinity DataKd:  540nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275232((1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydrophenant...)
Affinity DataKd:  31nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275233((1H-Benzoimidazol-2-yl)(7-phenyl-1,2,3,4-tetrahydr...)
Affinity DataKd:  600nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275234((S)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo...)
Affinity DataKd:  450nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50240909(2-Phenethyl-1H-benzoimidazole | 2-phenethyl-1H-ben...)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275235(CHEMBL486569 | N-(1H-benzo[d]imidazol-2-yl)-4-chlo...)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataKd:  100nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataEC50:  400nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataEC50:  1.81E+3nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp technique in presence of 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  7.80nMAssay Description:Inhibition of human SK3 channel expressed in HEK293 cells assessed as Ca2+ induced current after drug wash out by whole cell patch clamp technique in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  60nMAssay Description:Inhibition of human SK3 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  54nMAssay Description:Inhibition of human SK1 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275152(2-(2-Phenylpiperidin-1-yl)-1H-benzoimidazole | CHE...)
Affinity DataKd:  750nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275153(2-(2-Phenylpyrrolidin-1-yl)-1H-benzoimidazole | CH...)
Affinity DataKd:  1.60E+3nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50275154((1H-Benzoimidazol-2-yl)-(3,4-dichlorobenzyl)amine ...)
Affinity DataKd:  200nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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