Compile Data Set for Download or QSAR
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Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50027717
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of AURAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAurora kinase C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of AURCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKi:  5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  18nMAssay Description:Inhibition of AURBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  30nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Affinity DataIC50:  8nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  27nMAssay Description:Inhibition of TGFBR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLysine--tRNA ligase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1...)
Affinity DataIC50:  34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50273542(4'-Amino-4''-sulfamoyl-[1,1';3',1'']terphenyl-4,5'...)
Affinity DataIC50:  650nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 10(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241256(CHEMBL233000 | N-(3-cyano-4,5,6,7-tetrahydrobenzo[...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKd:  22nMAssay Description:Binding affinity to human JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  20nMAssay Description:Binding affinity to human EPHA6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241256(CHEMBL233000 | N-(3-cyano-4,5,6,7-tetrahydrobenzo[...)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to human AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  53nMAssay Description:Binding affinity to human AAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKd:  506nMAssay Description:Binding affinity to human INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyosin light chain kinase, smooth muscle(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Affinity DataKd:  150nMAssay Description:Binding affinity to human SKMLCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase 17A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  96nMAssay Description:Binding affinity to human DRAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCasein kinase I isoform gamma-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  59nMAssay Description:Binding affinity to human CK1gamma1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin receptor-related protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKd:  276nMAssay Description:Binding affinity to human IRRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKd:  85nMAssay Description:Binding affinity to human TNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  36nMAssay Description:Binding affinity to human BMXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Blk(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human BLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Yes(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  1nMAssay Description:Binding affinity to human YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fyn(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human FYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fgr(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human FGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein-tyrosine kinase 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human BRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase CSK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  28nMAssay Description:Binding affinity to human CSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase receptor TYRO3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  264nMAssay Description:Binding affinity to human TYRO3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to human EPHA3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  3nMAssay Description:Binding affinity to human EPHA5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human EPHA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-B receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  7nMAssay Description:Binding affinity to human EPHB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-B receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  81nMAssay Description:Binding affinity to human EPHB3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEphrin type-A receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  8nMAssay Description:Binding affinity to human EPHA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAtypical kinase COQ8B, mitochondrial(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataKd:  129nMAssay Description:Binding affinity to human ADCK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1...)
Affinity DataKd:  395nMAssay Description:Binding affinity to human TXKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSTE20-like serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1...)
Affinity DataKd:  623nMAssay Description:Binding affinity to human SLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase 16(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to human MPSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase MARK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Affinity DataKd:  207nMAssay Description:Binding affinity to human MARK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Affinity DataKd:  16nMAssay Description:Binding affinity to human PIM2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataKd:  1.87E+3nMAssay Description:Binding affinity to human ARGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase CLK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human CLK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCasein kinase I isoform alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  225nMAssay Description:Binding affinity to human CK1alpha2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCasein kinase I isoform delta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273635(1-(4-methyl-2,5-di(pyridin-4-yl)-1H-pyrrol-3-yl)et...)
Affinity DataKd:  58nMAssay Description:Binding affinity to human CK1deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  1.23E+3nMAssay Description:Binding affinity to human MNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase MARK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273636(4-(5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)benzami...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to human MARK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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