Compile Data Set for Download or QSAR
maximum 50k data
Found 27 Enz. Inhib. hit(s) with all data for entry = 50028035
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255925(CHEMBL474438 | N-((S)-4-fluoro-4-methyl-1-oxo-1-((...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255864(CHEMBL443434 | ethyl 3-((S)-4-fluoro-4-methyl-2-((...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255754((2S)-4-fluoro-4-methyl-N-(3-oxo-1-(pyridin-2-ylsul...)
Affinity DataIC50:  2nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255754((2S)-4-fluoro-4-methyl-N-(3-oxo-1-(pyridin-2-ylsul...)
Affinity DataIC50:  2nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255755(2-(4-((S)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255866((2S)-N-(1-benzoylpyrrolidin-3-yl)-4-fluoro-4-methy...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255865(CHEMBL452219 | tert-butyl 3-((S)-4-fluoro-4-methyl...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255867((2S)-N-(1-acetylpyrrolidin-3-yl)-4-fluoro-4-methyl...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255863(CHEMBL480922 | methyl 3-((S)-4-fluoro-4-methyl-2-(...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255817((S)-4-fluoro-4-methyl-N-(1-(pyridin-2-ylsulfonyl)p...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255924((S)-4-fluoro-4-methyl-N-(1-(2-(methylsulfonyl)phen...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255868(3-((S)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255869(3-((S)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255923((S)-4-fluoro-4-methyl-N-(1-phenylpiperidin-4-yl)-2...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255818(CHEMBL499380 | ethyl 4-((S)-4-fluoro-4-methyl-2-((...)
Affinity DataIC50:  9nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255821((2S)-4-fluoro-4-methyl-N-(pyrrolidin-3-yl)-2-((S)-...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255754((2S)-4-fluoro-4-methyl-N-(3-oxo-1-(pyridin-2-ylsul...)
Affinity DataIC50:  10nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255870(CHEMBL499527 | N-benzyl-3-((S)-4-fluoro-4-methyl-2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255757((2S)-4-fluoro-4-methyl-N-(1-(methylsulfonyl)-3-oxo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255820((2S)-4-fluoro-4-methyl-N-(1-(methylsulfonyl)pyrrol...)
Affinity DataIC50:  27nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255816((2S)-4-fluoro-4-methyl-N-(3-oxoazepan-4-yl)-2-((S)...)
Affinity DataIC50:  33nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255922(CHEMBL475434 | methyl 3-((S)-4-fluoro-4-methyl-2-(...)
Affinity DataIC50:  45nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255758(CHEMBL499218 | ethyl 4-((S)-4-fluoro-4-methyl-2-((...)
Affinity DataIC50:  54nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255871(3-((S)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-...)
Affinity DataIC50:  68nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255819((2S)-4-fluoro-4-methyl-N-(1-(pyridin-2-ylsulfonyl)...)
Affinity DataIC50:  85nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255756((2S)-N-(1-(benzylsulfonyl)-3-oxoazepan-4-yl)-4-flu...)
Affinity DataIC50:  159nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed