Compile Data Set for Download or QSAR
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Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 3136
TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28529(Azepino[4,5-b]indole, 1 | ethyl 3-[(4-fluorophenyl...)
Affinity DataEC50:  600nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28530(Azepino[4,5-b]indole, 6a | propan-2-yl 3-[(4-fluor...)
Affinity DataEC50:  500nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28531(Azepino[4,5-b]indole, 6b | propyl 3-[(4-fluorophen...)
Affinity DataEC50:  500nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28532(Azepino[4,5-b]indole, 6c | butyl 3-[(4-fluoropheny...)
Affinity DataEC50:  1.10E+3nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28533(Azepino[4,5-b]indole, 6d | ethyl 3-[(4-fluoropheny...)
Affinity DataEC50:  57nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28534(Azepino[4,5-b]indole, 6e | ethyl 3-[(4-chloropheny...)
Affinity DataEC50:  73nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28542(WAY-362450 | XL335 | propan-2-yl 3-[(3,4-difluorop...)
Affinity DataEC50:  4nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28536(Azepino[4,5-b]indole, 6g | ethyl 3-[(3,4-difluorop...)
Affinity DataEC50:  32nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28537(Azepino[4,5-b]indole, 6h | ethyl 3-[(4-fluoropheny...)
Affinity DataEC50:  22nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataEC50:  12nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28539(Azepino[4,5-b]indole, 6j | ethyl 3-[(4-chloropheny...)
Affinity DataEC50:  25nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28540(Azepino[4,5-b]indole, 6k | ethyl 3-[(4-methoxyphen...)
Affinity DataEC50:  29nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28541(Azepino[4,5-b]indole, 6l | propan-2-yl 3-[(4-fluor...)
Affinity DataEC50:  8nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile acid receptor(Human)
Exelixis

LigandPNGBDBM28535(Azepino[4,5-b]indole, 6f | ethyl 3-[(4-methoxyphen...)
Affinity DataEC50:  60nMpH: 7.0 T: 22°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed