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Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50038784
TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMu-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248968(14beta-Cinnamoyloxy-N-cyclopropylmethyl-7,8-dihydr...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249017(14-O-phenylpropylnaltrexone | 4-cyclopropylmethyl-...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248969(14beta-(4-Chlorocinnamoyloxy)-N-cyclopropylmethyl-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195656(14beta-4'-Chlorocinnamoylaminodihydronormorphinone...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248991(CHEMBL474755 | N-Cyclopropylmethyl-14beta-cinnamoy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195656(14beta-4'-Chlorocinnamoylaminodihydronormorphinone...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195656(14beta-4'-Chlorocinnamoylaminodihydronormorphinone...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248990(14beta-(4-Methylcinnamoyloxy)-N-cyclopropylmethyl-...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248992(CHEMBL512526 | N-Cyclopropylmethyl-14beta-4'-chlor...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248968(14beta-Cinnamoyloxy-N-cyclopropylmethyl-7,8-dihydr...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249016(CHEMBL471543 | N-Cyclopropylmethyl-14beta-4'-methy...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248991(CHEMBL474755 | N-Cyclopropylmethyl-14beta-cinnamoy...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195674(1N-[4-cyclopropylmethyl-10-methoxy-14-oxo-(17S)-12...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195674(1N-[4-cyclopropylmethyl-10-methoxy-14-oxo-(17S)-12...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248990(14beta-(4-Methylcinnamoyloxy)-N-cyclopropylmethyl-...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Guinea pig)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248969(14beta-(4-Chlorocinnamoyloxy)-N-cyclopropylmethyl-...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in Hartely guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195674(1N-[4-cyclopropylmethyl-10-methoxy-14-oxo-(17S)-12...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249016(CHEMBL471543 | N-Cyclopropylmethyl-14beta-4'-methy...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248992(CHEMBL512526 | N-Cyclopropylmethyl-14beta-4'-chlor...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248992(CHEMBL512526 | N-Cyclopropylmethyl-14beta-4'-chlor...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248991(CHEMBL474755 | N-Cyclopropylmethyl-14beta-cinnamoy...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249016(CHEMBL471543 | N-Cyclopropylmethyl-14beta-4'-methy...)
Affinity DataKi:  270nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  484nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  16nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248991(CHEMBL474755 | N-Cyclopropylmethyl-14beta-cinnamoy...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50195674(1N-[4-cyclopropylmethyl-10-methoxy-14-oxo-(17S)-12...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50249016(CHEMBL471543 | N-Cyclopropylmethyl-14beta-4'-methy...)
Affinity DataEC50:  157nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248991(CHEMBL474755 | N-Cyclopropylmethyl-14beta-cinnamoy...)
Affinity DataEC50:  34nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50248991(CHEMBL474755 | N-Cyclopropylmethyl-14beta-cinnamoy...)
Affinity DataEC50:  430nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed