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Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 3125
TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28404((2E)-3-{3-[6-(1,4-diazepan-1-yl)pyrazin-2-yl]pheny...)
Affinity DataIC50:  10nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28397((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Affinity DataIC50:  12nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28397((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Affinity DataIC50:  13nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28417((2E)-3-(3-{6-[4-(aminomethyl)piperidin-1-yl]pyrazi...)
Affinity DataIC50:  17nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28418((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Affinity DataIC50:  19nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28395((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Affinity DataIC50:  22nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28416((2E)-3-(3-{6-[(piperidin-4-ylmethyl)amino]pyrazin-...)
Affinity DataIC50:  25nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28411((2E)-3-(3-{6-[(3-aminopropyl)amino]pyrazin-2-yl}ph...)
Affinity DataIC50:  27nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28395((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Affinity DataIC50:  33nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50:  40nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28398((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyridin-2...)
Affinity DataIC50:  46nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28398((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyridin-2...)
Affinity DataIC50:  50nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50:  57nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28412((2E)-3-[3-(6-{[3-(dimethylamino)propyl]amino}pyraz...)
Affinity DataIC50:  94nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28410((2E)-3-(3-{6-[(2-aminoethyl)amino]pyrazin-2-yl}phe...)
Affinity DataIC50:  140nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28407((2E)-3-{3-[6-(4-methylpiperazin-1-yl)pyrazin-2-yl]...)
Affinity DataIC50:  150nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28402(1-methyl-4-(6-{3-[(E)-2-(1H-1,2,3,4-tetrazol-5-yl)...)
Affinity DataIC50:  160nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28408((2E)-3-{3-[6-(piperazin-1-yl)pyrazin-2-yl]phenyl}p...)
Affinity DataIC50:  200nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28419((2E)-3-(3-{6-[(4-hydroxycyclohexyl)amino]pyrazin-2...)
Affinity DataIC50:  265nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28415((2E)-3-(3-{6-[(3-hydroxypropyl)amino]pyrazin-2-yl}...)
Affinity DataIC50:  310nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28396((2E)-3-(3-{6-[(3-methoxypropyl)amino]pyrazin-2-yl}...)
Affinity DataIC50:  370nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28413((2E)-3-[3-(6-{[3-(dimethylamino)propyl](methyl)ami...)
Affinity DataIC50:  370nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28396((2E)-3-(3-{6-[(3-methoxypropyl)amino]pyrazin-2-yl}...)
Affinity DataIC50:  480nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28406((2E)-3-{3-[6-(4-acetyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50:  880nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28414((2E)-3-(3-{6-[(2-acetamidoethyl)amino]pyrazin-2-yl...)
Affinity DataIC50:  1.02E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28400((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50:  1.20E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28401(3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]p...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28409((2E)-3-{3-[6-(morpholin-4-yl)pyrazin-2-yl]phenyl}p...)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28420((2E)-3-[3-(pyrazin-2-yl)phenyl]prop-2-enoic acid |...)
Affinity DataIC50:  2.20E+3nMAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28405((2E)-3-{3-[6-(azepan-1-yl)pyrazin-2-yl]phenyl}prop...)
Affinity DataIC50:  3.30E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28403(1-methyl-4-(pyrazin-2-yl)-1,4-diazepane | pyrazine...)
Affinity DataIC50: >8.00E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM28399(methyl (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)py...)
Affinity DataIC50: >8.00E+3nMpH: 7.5 T: 22°CAssay Description:The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed