Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 3379
TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32383(adenosine-derived inhibitor, 17)
Affinity DataIC50: <400nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM2(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)
Affinity DataIC50:  500nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataIC50:  500nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32378(adenosine-derived inhibitor (Grp78), 13 | adenosin...)
Affinity DataIC50:  500nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32382(adenosine-derived inhibitor, 16)
Affinity DataIC50:  600nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32381(adenosine-derived inhibitor (Grp78), 14 | adenosin...)
Affinity DataIC50:  900nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32379(adenosine-derived inhibitor, 13)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32380(adenosine-derived inhibitor, 14)
Affinity DataIC50:  1.70E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32377(adenosine-derived inhibitor (Grp78), 12 | adenosin...)
Affinity DataIC50:  2.40E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataIC50:  2.90E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32376(adenosine-derived inhibitor (Grp78), 11 | adenosin...)
Affinity DataIC50:  3.20E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32374(adenosine-derived inhibitor, 8)
Affinity DataIC50:  4.90E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32373(adenosine-derived inhibitor (Grp78), 8 | adenosine...)
Affinity DataIC50:  9.10E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32370(adenosine-derived inhibitor (Grp78), 2 | adenosine...)
Affinity DataIC50:  9.40E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32372(adenosine-derived inhibitor, 6)
Affinity DataIC50:  1.00E+4nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)
Affinity DataIC50:  1.70E+4nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM14487((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)
Affinity DataIC50:  5.60E+5nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32379(adenosine-derived inhibitor, 13)
Affinity DataKd:  200nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32380(adenosine-derived inhibitor, 14)
Affinity DataKd:  4.20E+3nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32381(adenosine-derived inhibitor (Grp78), 14 | adenosin...)
Affinity DataKd:  50nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32382(adenosine-derived inhibitor, 16)
Affinity DataKd:  60nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32383(adenosine-derived inhibitor, 17)
Affinity DataKd:  120nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32370(adenosine-derived inhibitor (Grp78), 2 | adenosine...)
Affinity DataKd:  1.10E+4nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKd:  500nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32378(adenosine-derived inhibitor (Grp78), 13 | adenosin...)
Affinity DataKd:  300nMpH: 7.4 T: 25°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)