Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 3243
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 26503BDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29796BDBM29796(sulfonamide tricyclic analogue, 7)
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29815BDBM29815(sulfonamide tricyclic analogue, 28)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29794BDBM29794(sulfonamide tricyclic analogue, 5)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29777BDBM29777(BMCL193674 Compound 8 | 7,6,5 tricyclic sulfonamid...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29805BDBM29805(sulfone tricyclic analogue, 18)
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29809BDBM29809(sulfonamide tricyclic analogue, 22)
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29804BDBM29804(sulfonamide tricyclic analogue, 15)
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 10145BDBM10145(methyl N-[(1S)-1-{[(5R)-5-[(4-aminobenzene)(2-meth...)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29800BDBM29800(sulfonamide tricyclic analogue, 11)
Affinity DataIC50: 11nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29775BDBM29775(BMCL193674 Compound 6 | 7,6,5 tricyclic sulfonamid...)
Affinity DataIC50: 15nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29812BDBM29812(sulfonamide tricyclic analogue, 25)
Affinity DataIC50: 20nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 26510BDBM26510(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 20nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29799BDBM29799(sulfonamide tricyclic analogue, 10)
Affinity DataIC50: 22nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29802BDBM29802(sulfonamide tricyclic analogue, 13)
Affinity DataIC50: 23nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29777BDBM29777(BMCL193674 Compound 8 | 7,6,5 tricyclic sulfonamid...)
Affinity DataIC50: 28nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29813BDBM29813(sulfonamide tricyclic analogue, 26)
Affinity DataIC50: 32nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29811BDBM29811(sulfonamide tricyclic analogue, 24)
Affinity DataIC50: 40nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29803BDBM29803(sulfonamide tricyclic analogue, 14)
Affinity DataIC50: 48nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29810BDBM29810(sulfonamide tricyclic analogue, 23)
Affinity DataIC50: 50nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 26503BDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)
Affinity DataIC50: 59nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29801BDBM29801(sulfonamide tricyclic analogue, 12)
Affinity DataIC50: 73nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29796BDBM29796(sulfonamide tricyclic analogue, 7)
Affinity DataIC50: 75nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29814BDBM29814(sulfonamide tricyclic analogue, 27)
Affinity DataIC50: 79nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29806BDBM29806(sulfone tricyclic analogue, 19)
Affinity DataIC50: 86nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29806BDBM29806(sulfone tricyclic analogue, 19)
Affinity DataIC50: 130nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29808BDBM29808(sulfone tricyclic analogue, 21)
Affinity DataIC50: 250nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29805BDBM29805(sulfone tricyclic analogue, 18)
Affinity DataIC50: 260nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 26510BDBM26510(N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 263nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29807BDBM29807(sulfone tricyclic analogue, 20)
Affinity DataIC50: 360nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29804BDBM29804(sulfonamide tricyclic analogue, 15)
Affinity DataIC50: 370nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 10145BDBM10145(methyl N-[(1S)-1-{[(5R)-5-[(4-aminobenzene)(2-meth...)
Affinity DataIC50: 420nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29799BDBM29799(sulfonamide tricyclic analogue, 10)
Affinity DataIC50: 430nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29806BDBM29806(sulfone tricyclic analogue, 19)
Affinity DataIC50: 450nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29775BDBM29775(BMCL193674 Compound 6 | 7,6,5 tricyclic sulfonamid...)
Affinity DataIC50: 490nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29796BDBM29796(sulfonamide tricyclic analogue, 7)
Affinity DataIC50: 570nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29794BDBM29794(sulfonamide tricyclic analogue, 5)
Affinity DataIC50: 590nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29777BDBM29777(BMCL193674 Compound 8 | 7,6,5 tricyclic sulfonamid...)
Affinity DataIC50: 890nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29803BDBM29803(sulfonamide tricyclic analogue, 14)
Affinity DataIC50: 1.14E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29808BDBM29808(sulfone tricyclic analogue, 21)
Affinity DataIC50: 1.15E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 10145BDBM10145(methyl N-[(1S)-1-{[(5R)-5-[(4-aminobenzene)(2-meth...)
Affinity DataIC50: 1.19E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 26503BDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)
Affinity DataIC50: 1.26E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29800BDBM29800(sulfonamide tricyclic analogue, 11)
Affinity DataIC50: 1.49E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29794BDBM29794(sulfonamide tricyclic analogue, 5)
Affinity DataIC50: 2.11E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29805BDBM29805(sulfone tricyclic analogue, 18)
Affinity DataIC50: 2.16E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29802BDBM29802(sulfonamide tricyclic analogue, 13)
Affinity DataIC50: 2.17E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29808BDBM29808(sulfone tricyclic analogue, 21)
Affinity DataIC50: 2.97E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29801BDBM29801(sulfonamide tricyclic analogue, 12)
Affinity DataIC50: 3.10E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29807BDBM29807(sulfone tricyclic analogue, 20)
Affinity DataIC50: 3.20E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandChemical structure of BindingDB Monomer ID 29799BDBM29799(sulfonamide tricyclic analogue, 10)
Affinity DataIC50: 5.43E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
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