Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50033471
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320996BDBM50320996(6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenyl...)
Affinity DataEC50:  45nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346000BDBM50346000((S)-2-(4-(cyclobutylsulfonyl)-2-oxopyridin-1(2H)-y...)
Affinity DataEC50:  60nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346002BDBM50346002((S)-2-(3-chloro-4-(isopropylsulfonyl)-2-oxopyridin...)
Affinity DataEC50:  70nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346001BDBM50346001((S)-3-cyclopentyl-2-(4-(cyclopropylsulfonyl)-2-oxo...)
Affinity DataEC50:  110nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346003BDBM50346003((S)-2-(5-chloro-4-(methylsulfonyl)-2-oxopyridin-1(...)
Affinity DataEC50:  140nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346004BDBM50346004((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-5-methy...)
Affinity DataEC50:  160nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346005BDBM50346005((S)-3-(4,4-difluorocyclohexyl)-2-(4-(isopropylsulf...)
Affinity DataEC50:  160nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50251391BDBM50251391((2R)-2-(4-Cyclopropanesulfonylphenyl)-N-(5-fluorot...)
Affinity DataEC50:  180nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346006BDBM50346006((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-2-oxopy...)
Affinity DataEC50:  230nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346007BDBM50346007((S)-3-cyclohexyl-2-(4-(isopropylsulfonyl)-2-oxopyr...)
Affinity DataEC50:  240nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346008BDBM50346008((S)-2-(5-chloro-4-(isopropylsulfonyl)-2-oxopyridin...)
Affinity DataEC50:  260nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346009BDBM50346009((S)-2-(4-(cyclobutylsulfonyl)-2-oxopyridin-1(2H)-y...)
Affinity DataEC50:  260nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346010BDBM50346010((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-2-oxopy...)
Affinity DataEC50:  330nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346011BDBM50346011((S)-3-cyclopentyl-2-(5-methyl-4-(methylsulfonyl)-2...)
Affinity DataEC50:  440nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346013BDBM50346013((S)-2-(5-chloro-4-(methylsulfonyl)-2-oxopyridin-1(...)
Affinity DataEC50:  480nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346012BDBM50346012((S)-3-cyclopentyl-2-(4-(ethylsulfonyl)-2-oxopyridi...)
Affinity DataEC50:  500nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346014BDBM50346014((S)-2-(4-(isopropylsulfonyl)-2-oxopyridin-1(2H)-yl...)
Affinity DataEC50:  510nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346015BDBM50346015((S)-3-cyclopentyl-N-(5-methylpyridin-2-yl)-2-(4-(m...)
Affinity DataEC50:  560nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346016BDBM50346016((S)-2-(4-(cyclobutylsulfonyl)-2-oxopyridin-1(2H)-y...)
Affinity DataEC50:  590nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346017BDBM50346017((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-2-oxopy...)
Affinity DataEC50:  600nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346018BDBM50346018(2-amino-4-fluoro-5-(1-methyl-1H-imidazol-2-ylthio)...)
Affinity DataEC50:  620nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346019BDBM50346019((S)-3-cyclobutyl-2-(4-(isopropylsulfonyl)-2-oxopyr...)
Affinity DataEC50:  670nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346020BDBM50346020((2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-t...)
Affinity DataEC50:  690nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346021BDBM50346021((S)-2-(5-chloro-4-(isopropylsulfonyl)-2-oxopyridin...)
Affinity DataEC50:  700nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346022BDBM50346022((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-2-oxopy...)
Affinity DataEC50:  720nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346023BDBM50346023((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-2-oxopy...)
Affinity DataEC50:  910nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346024BDBM50346024((S)-3-cyclopentyl-2-(4-(cyclopropylsulfonyl)-2-oxo...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346025BDBM50346025((S)-3-cyclopentyl-2-(4-(isopropylsulfonyl)-2-oxopy...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346026BDBM50346026((R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3...)
Affinity DataEC50:  1.42E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346027BDBM50346027((S)-2-(4-(ethylsulfonyl)-2-oxopyridin-1(2H)-yl)-N-...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346028BDBM50346028((S)-3-cyclopentyl-2-(4-(cyclopropylsulfonyl)-2-oxo...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346029BDBM50346029((S)-2-(4-(isopropylsulfonyl)-2-oxopyridin-1(2H)-yl...)
Affinity DataEC50:  3.30E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50346030BDBM50346030((S)-3-cyclopentyl-N-(5-methylpyrazin-2-yl)-2-(4-(m...)
Affinity DataEC50:  3.50E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed