Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50030471
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296637BDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296653BDBM50296653(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296657BDBM50296657(4-chloro-N-cyclopropyl-3-(1-(2,5-difluorophenyl)-7...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296661BDBM50296661(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296644BDBM50296644(3-(1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296651BDBM50296651(4-chloro-N-cyclopropyl-3-(7-ethyl-1-(4-fluoropheny...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296663BDBM50296663(N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296662BDBM50296662(N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296660BDBM50296660(N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296642BDBM50296642(3-(1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296656BDBM50296656(N-cyclopropyl-3-(1-(2,5-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296645BDBM50296645(N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296648BDBM50296648(N-cyclopropyl-3-(1-(3-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296659BDBM50296659(4-chloro-N-cyclopropyl-3-(1-(2,5-difluorophenyl)-7...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296643BDBM50296643(3-(1-(2,5-difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296650BDBM50296650(N-cyclopropyl-3-(7-ethyl-1-(4-fluorophenyl)-6-oxo-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296652BDBM50296652(N-cyclopropyl-3-(7-ethyl-1-(4-fluorophenyl)-6-oxo-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 4nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296658BDBM50296658(N-cyclopropyl-3-(1-(2,5-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296655BDBM50296655(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296649BDBM50296649(N-cyclopropyl-3-(1-(3-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296654BDBM50296654(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296646BDBM50296646(N-tert-butyl-3-(1-(2,4-difluorophenyl)-7-methyl-6-...)
Affinity DataIC50: 269nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296641BDBM50296641(1-(2,5-difluorophenyl)-7-methyl-4-(4-methylpyridin...)
Affinity DataIC50: 444nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296638BDBM50296638(1-(3-fluorophenyl)-7-methyl-4-(tetrahydro-2H-pyran...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296639BDBM50296639(1-(2,6-difluorophenyl)-4-(4-fluorophenylamino)-7-m...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296640BDBM50296640(1-(2,4-difluorophenyl)-4-(2,4-difluorophenylamino)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296647BDBM50296647(3-(1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylation of ATF2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296637BDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296637BDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296637BDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50296636BDBM50296636(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed