Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50030472
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296674((E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone | C...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296665(Adamantan-1-yl-[2-(6-morpholin-4-yl-2-pyridin-3-yl...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296665(Adamantan-1-yl-[2-(6-morpholin-4-yl-2-pyridin-3-yl...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human GluR1 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296677(Adamantan-1-yl-(2-quinolin-3-yl-cyclopropyl)-metha...)
Affinity DataKi:  137nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296676((E)-1-Adamantan-1-yl-3-(4-methoxy-3-methyl-phenyl)...)
Affinity DataKi:  294nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296679(Adamantan-1-yl-[2-(6-methoxy-pyridin-3-yl)-cyclopr...)
Affinity DataKi:  304nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296675((E)-1-Adamantan-1-yl-3-(2,3-dihydro-benzo[1,4]diox...)
Affinity DataKi:  641nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296666(3-(2-chloro-6-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataIC50: 740nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296674((E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone | C...)
Affinity DataKi:  807nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296668(3-(2-chloro-6-methylquinolin-3-yl)-1-phenylprop-2-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296669(3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataIC50: 2.97E+3nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296676((E)-1-Adamantan-1-yl-3-(4-methoxy-3-methyl-phenyl)...)
Affinity DataKi:  5.15E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296673((E)-4,4-Dimethyl-1-quinolin-3-yl-pent-1-en-3-one |...)
Affinity DataKi:  5.23E+3nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296675((E)-1-Adamantan-1-yl-3-(2,3-dihydro-benzo[1,4]diox...)
Affinity DataKi:  6.23E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296678(Adamantan-1-yl-(2-pyridin-3-yl-cyclopropyl)-methan...)
Affinity DataKi:  7.04E+3nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296667(3-(2-chloro-8-methylquinolin-3-yl)-1-phenylprop-2-...)
Affinity DataIC50: 8.50E+3nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296668(3-(2-chloro-6-methylquinolin-3-yl)-1-phenylprop-2-...)
Affinity DataKi:  9.18E+3nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296666(3-(2-chloro-6-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataKi:  9.93E+3nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296700(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylbu...)
Affinity DataIC50: 1.06E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296685((3,4-dimethylphenyl)(4-phenoxyphenyl)methanone | C...)
Affinity DataIC50: 1.53E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296669(3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-y...)
Affinity DataKi:  1.72E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296679(Adamantan-1-yl-[2-(6-methoxy-pyridin-3-yl)-cyclopr...)
Affinity DataKi:  1.84E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296670(3-(2-chloro-6-methylquinolin-3-yl)-1-(4-methoxyphe...)
Affinity DataIC50: 2.05E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296683(4-(5-pentylpyridin-2-yl)phenyl 4-ethylcyclohexanec...)
Affinity DataIC50: 2.25E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296678(Adamantan-1-yl-(2-pyridin-3-yl-cyclopropyl)-methan...)
Affinity DataKi:  2.29E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296682(8-hexyl-7-methoxy-2,3-dihydrocyclopenta[c]chromen-...)
Affinity DataIC50: 2.39E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296690(7-(4-fluorobenzyloxy)-4-phenyl-2H-chromen-2-one | ...)
Affinity DataIC50: 2.39E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296665(Adamantan-1-yl-[2-(6-morpholin-4-yl-2-pyridin-3-yl...)
Affinity DataKi:  2.78E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296696(2-(biphenyl-4-yl)-5-(4-butoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 2.84E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296691(3-(4-chlorophenyl)-1-(4-phenoxyphenyl)prop-2-en-1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296673((E)-4,4-Dimethyl-1-quinolin-3-yl-pent-1-en-3-one |...)
Affinity DataKi:  3.06E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296700(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylbu...)
Affinity DataKi:  3.62E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296664(3-(2-chloro-7-methylquinolin-3-yl)-1-(4-methoxyphe...)
Affinity DataIC50: 3.93E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296682(8-hexyl-7-methoxy-2,3-dihydrocyclopenta[c]chromen-...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296698(2,4-bis(3-bromo-4-methoxyphenyl)-6-methylpyridine ...)
Affinity DataIC50: 4.00E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296683(4-(5-pentylpyridin-2-yl)phenyl 4-ethylcyclohexanec...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296664(3-(2-chloro-7-methylquinolin-3-yl)-1-(4-methoxyphe...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296693(6-chloro-7-(4-fluorobenzyloxy)-4-phenyl-2H-chromen...)
Affinity DataIC50: 4.00E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296681(4-acetylphenyl 4-butylcyclohexanecarboxylate | CHE...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296687(1-(4-methoxyphenyl)-3-(4-(thietan-3-yloxy)phenyl)p...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296684(3-(1-phenylethoxy)-6H-benzo[c]chromen-6-one | CHEM...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296697((4-chlorophenyl)(2,3,4,5-tetrahydrobenzo[b]oxepin-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296685((3,4-dimethylphenyl)(4-phenoxyphenyl)methanone | C...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296690(7-(4-fluorobenzyloxy)-4-phenyl-2H-chromen-2-one | ...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296691(3-(4-chlorophenyl)-1-(4-phenoxyphenyl)prop-2-en-1-...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296684(3-(1-phenylethoxy)-6H-benzo[c]chromen-6-one | CHEM...)
Affinity DataIC50: 4.00E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296688(4-cyclohexylphenyl 4-(hexyloxy)benzoate | CHEMBL56...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296686(7-(3-phenoxybenzyloxy)-4-phenyl-2H-chromen-2-one |...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296694(1-benzyl-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroiso...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296699(3-(4-(2,4-dichlorobenzyloxy)phenyl)-1-(4-ethoxyphe...)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
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