Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50030552
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297936BDBM50297936(2-Hydroxy-2-phenethyl-pentanedioic acid 5-{[3-(met...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297935BDBM50297935(2-Hydroxy-2-phenethyl-pentanedioic acid 1-[((S)-1-...)
Affinity DataIC50: 450nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297934BDBM50297934(2-Hydroxy-2-phenethyl-pentanedioic acid 1-[((1S,2R...)
Affinity DataIC50: 570nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297933BDBM50297933((S)-2-Benzyl-2-hydroxy-pentanedioic acid 1-[((1S,2...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297929BDBM50297929(4-((S)-2-{4-[3-[(R)-1-(4-Fluoro-phenyl)-ethylcarba...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297932BDBM50297932((R)-2-Benzyl-2-hydroxy-pentanedioic acid 1-[((1S,2...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297936BDBM50297936(2-Hydroxy-2-phenethyl-pentanedioic acid 5-{[3-(met...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of human liver cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297934BDBM50297934(2-Hydroxy-2-phenethyl-pentanedioic acid 1-[((1S,2R...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of human liver cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297927BDBM50297927(2-Hydroxy-2-phenethyl-pentanedioic acid 5-[((S)-1-...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297925BDBM50297925(2-Benzyl-2-hydroxy-pentanedioic acid 5-[((S)-1-ben...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297926BDBM50297926(2-Hydroxy-2-phenethyl-pentanedioic acid 5-[((S)-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297930BDBM50297930(4-[((S)-2-{4-[3-[(R)-1-(4-Fluoro-phenyl)-ethylcarb...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297931BDBM50297931(4-((S)-2-{4-[3-[(R)-1-(4-Fluoro-phenyl)-ethylcarba...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297938BDBM50297938(2-Benzyl-2-hydroxy-pentanedioic acid 1-{[3-[(R)-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297928BDBM50297928(4-[((S)-2-{4-[3-[(R)-1-(4-Fluoro-phenyl)-ethylcarb...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Swedish mutant sequence Eu-EVNLDAEFK-Quencher substrate by homogeneous time r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed