Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50030814
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301971(2-((S)-6-(2,6-difluorophenyl)-3,3-dimethyl-2-oxopi...)
Affinity DataKi:  0.0350nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301969(2a-(aminomethyl)-1-(((S)-2'-oxo-1',2',6,8-tetrahyd...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301968(CHEMBL570474 | N-((R)-1-(3,5-difluorophenyl)ethyl)...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301963((S)-N-(3,5-difluorobenzyl)-N-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301967(CHEMBL583679 | N-(2-((S)-3-methyl-2,5-dioxo-1',3'-...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301964((S)-N-(3-chloro-5-fluorobenzyl)-N-(2-(3-methyl-2,5...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301956((+/-)-N-(3-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301958((+/-)-N-(3-chlorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301954((S)-N-benzyl-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydr...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301957((+/-)-N-(4-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301965((S)-N-(3,5-dichlorobenzyl)-N-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301959((+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301955((+/-)-N-(2-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301961((+/-)-N-(3-cyanobenzyl)-N-(2-(3-methyl-2,5-dioxo-1...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301962((+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301960((+/-)-N-(3-methoxybenzyl)-N-(2-(3-methyl-2,5-dioxo...)
Affinity DataKi:  45nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301966(CHEMBL568880 | N-(2-((S)-3-methyl-2,5-dioxo-1',3'-...)
Affinity DataKi:  56nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301967(CHEMBL583679 | N-(2-((S)-3-methyl-2,5-dioxo-1',3'-...)
Affinity DataKi:  670nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301954((S)-N-benzyl-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydr...)
Affinity DataKi:  710nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301970((R)-N-benzyl-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydr...)
Affinity DataKi:  800nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301956((+/-)-N-(3-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301958((+/-)-N-(3-chlorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301968(CHEMBL570474 | N-((R)-1-(3,5-difluorophenyl)ethyl)...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301959((+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301964((S)-N-(3-chloro-5-fluorobenzyl)-N-(2-(3-methyl-2,5...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301965((S)-N-(3,5-dichlorobenzyl)-N-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301963((S)-N-(3,5-difluorobenzyl)-N-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301957((+/-)-N-(4-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301962((+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[...)
Affinity DataKi:  6.20E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301960((+/-)-N-(3-methoxybenzyl)-N-(2-(3-methyl-2,5-dioxo...)
Affinity DataKi:  9.70E+3nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301961((+/-)-N-(3-cyanobenzyl)-N-(2-(3-methyl-2,5-dioxo-1...)
Affinity DataKi:  1.30E+4nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301966(CHEMBL568880 | N-(2-((S)-3-methyl-2,5-dioxo-1',3'-...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [125I]adrenomedullin from human cloned AM2 receptor expressed in B6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301971(2-((S)-6-(2,6-difluorophenyl)-3,3-dimethyl-2-oxopi...)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50301969(2a-(aminomethyl)-1-(((S)-2'-oxo-1',2',6,8-tetrahyd...)
Affinity DataIC50:  0.620nMAssay Description:Antagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed