Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50031312
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310938BDBM50310938(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310948BDBM50310948(5-((3-chloro-10-methyl-9H-benzo[f]imidazo[1,5-a][1...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310947BDBM50310947(5-((3,10-dimethyl-9H-benzo[f]imidazo[1,5-a][1,2,4]...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310937BDBM50310937(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310946BDBM50310946(10-methyl-6-((3-methylisoxazol-5-yl)methyl)-9H-ben...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144861BDBM50144861(3-(5-Methyl-isoxazol-3-yl)-6-(pyridin-2-ylmethoxy)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50144861BDBM50144861(3-(5-Methyl-isoxazol-3-yl)-6-(pyridin-2-ylmethoxy)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144861BDBM50144861(3-(5-Methyl-isoxazol-3-yl)-6-(pyridin-2-ylmethoxy)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50144861BDBM50144861(3-(5-Methyl-isoxazol-3-yl)-6-(pyridin-2-ylmethoxy)...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310945BDBM50310945(3-methyl-5-((10-methyl-9H-benzo[f]imidazo[1,5-a][1...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310944BDBM50310944(5-((3-methoxy-10-methyl-9H-benzo[f]imidazo[1,5-a][...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310935BDBM50310935(3-bromo-6-(cyclopropylmethyl)-10-methyl-9H-benzo[f...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310939BDBM50310939(3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,2,4]...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310936BDBM50310936(1-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310943BDBM50310943(3-methyl-5-((10-methyl-3-(trifluoromethoxy)-9H-ben...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310942BDBM50310942(3-bromo-6-(methoxymethyl)-10-methyl-9H-benzo[f]imi...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310941BDBM50310941(3-bromo-6,10-dimethyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310938BDBM50310938(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  73nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310938BDBM50310938(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  105nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310939BDBM50310939(3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,2,4]...)
Affinity DataKi:  132nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310939BDBM50310939(3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,2,4]...)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310940BDBM50310940(3-bromo-6-tert-butyl-10-methyl-9H-benzo[f]imidazo[...)
Affinity DataKi:  146nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310939BDBM50310939(3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,2,4]...)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310938BDBM50310938(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  188nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310937BDBM50310937(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  277nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310937BDBM50310937(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  317nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310935BDBM50310935(3-bromo-6-(cyclopropylmethyl)-10-methyl-9H-benzo[f...)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310935BDBM50310935(3-bromo-6-(cyclopropylmethyl)-10-methyl-9H-benzo[f...)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310937BDBM50310937(5-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  469nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310936BDBM50310936(1-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  515nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310935BDBM50310935(3-bromo-6-(cyclopropylmethyl)-10-methyl-9H-benzo[f...)
Affinity DataKi:  538nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310942BDBM50310942(3-bromo-6-(methoxymethyl)-10-methyl-9H-benzo[f]imi...)
Affinity DataKi:  592nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310942BDBM50310942(3-bromo-6-(methoxymethyl)-10-methyl-9H-benzo[f]imi...)
Affinity DataKi:  619nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310936BDBM50310936(1-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  624nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310936BDBM50310936(1-((3-bromo-10-methyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  669nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310942BDBM50310942(3-bromo-6-(methoxymethyl)-10-methyl-9H-benzo[f]imi...)
Affinity DataKi:  693nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310940BDBM50310940(3-bromo-6-tert-butyl-10-methyl-9H-benzo[f]imidazo[...)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310940BDBM50310940(3-bromo-6-tert-butyl-10-methyl-9H-benzo[f]imidazo[...)
Affinity DataKi:  1.21E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310941BDBM50310941(3-bromo-6,10-dimethyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  1.42E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310941BDBM50310941(3-bromo-6,10-dimethyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-3-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310941BDBM50310941(3-bromo-6,10-dimethyl-9H-benzo[f]imidazo[1,5-a][1,...)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-2-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50310940BDBM50310940(3-bromo-6-tert-butyl-10-methyl-9H-benzo[f]imidazo[...)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA alpha-1-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed