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Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50030677
TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300018(2-(4-(Oxazol-5-yl)phenyl)-1H-benzo[d]imidazole-4-c...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300015(2-(4-(Pyridin-3-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300008(2-(4-(1,3,4-Oxadiazol-2-yl)phenyl)-1H-benzo[d]imid...)
Affinity DataKi:  1nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300019(2-(4-(1H-Imidazol-5-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300009(2-(4-(5-Oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300021(2-(4-(Thiazol-4-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300016(2-(4-(Pyridin-2-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300017(2-(biphenyl-4-yl)-1H-benzo[d]imidazole-4-carboxami...)
Affinity DataKi:  2nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300020(2-(4-(1H-Imidazol-2-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300023(2-(4-(2-Aminothiazol-4-yl)phenyl)-1H-benzo[d]imida...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300022(2-(4-(2-Methyloxazol-4-yl)phenyl)-1H-benzo[d]imida...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300005(2-(4-(Imidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo[...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300014(2-(4-(Pyridin-4-yl)phenyl)-1H-benzimidazole-4-carb...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300011(2-(4-(5-Thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)ph...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300007(2-(4-(3-Methyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-ben...)
Affinity DataKi:  4nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300013(2-(4-(1-Methyl-1H-pyrazol-3-yl)phenyl)-1H-benzo[d]...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)
Affinity DataKi:  5nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300010(2-(4-(5-Oxo-4,5-dihydro-1,2,4-thiadiazol-3-yl)phen...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300006(2-(4-(7-(Trifluoromethyl)imidazo[1,2-a]pyridin-2-y...)
Affinity DataKi:  6.80nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27119(2-(1-propylpiperidin-4-yl)-1H-1,3-benzodiazole-4-c...)
Affinity DataKi:  8nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300012(2-(4-(Isoxazol-5-yl)phenyl)-1H-benzo[d]imidazole-4...)
Affinity DataKi:  10nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300025(2-(4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  16nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300024(2-(4-(1H-Tetrazol-5-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataKi:  20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300022(2-(4-(2-Methyloxazol-4-yl)phenyl)-1H-benzo[d]imida...)
Affinity DataEC50:  18nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300021(2-(4-(Thiazol-4-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataEC50:  3.70nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300020(2-(4-(1H-Imidazol-2-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300019(2-(4-(1H-Imidazol-5-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  3.70nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300018(2-(4-(Oxazol-5-yl)phenyl)-1H-benzo[d]imidazole-4-c...)
Affinity DataEC50:  0.990nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27135(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazo...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300017(2-(biphenyl-4-yl)-1H-benzo[d]imidazole-4-carboxami...)
Affinity DataEC50:  71nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27119(2-(1-propylpiperidin-4-yl)-1H-1,3-benzodiazole-4-c...)
Affinity DataEC50:  3nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300016(2-(4-(Pyridin-2-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataEC50:  7.80nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300015(2-(4-(Pyridin-3-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataEC50:  9nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300014(2-(4-(Pyridin-4-yl)phenyl)-1H-benzimidazole-4-carb...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300013(2-(4-(1-Methyl-1H-pyrazol-3-yl)phenyl)-1H-benzo[d]...)
Affinity DataEC50:  20nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300012(2-(4-(Isoxazol-5-yl)phenyl)-1H-benzo[d]imidazole-4...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300011(2-(4-(5-Thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)ph...)
Affinity DataEC50:  328nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300010(2-(4-(5-Oxo-4,5-dihydro-1,2,4-thiadiazol-3-yl)phen...)
Affinity DataEC50:  461nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300009(2-(4-(5-Oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataEC50:  64nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300008(2-(4-(1,3,4-Oxadiazol-2-yl)phenyl)-1H-benzo[d]imid...)
Affinity DataEC50:  3.70nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300007(2-(4-(3-Methyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-ben...)
Affinity DataEC50:  9.10nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300023(2-(4-(2-Aminothiazol-4-yl)phenyl)-1H-benzo[d]imida...)
Affinity DataEC50:  26nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300005(2-(4-(Imidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo[...)
Affinity DataEC50:  20nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300006(2-(4-(7-(Trifluoromethyl)imidazo[1,2-a]pyridin-2-y...)
Affinity DataEC50:  20nMAssay Description:Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed