Compile Data Set for Download or QSAR
Report error Found 84 Enz. Inhib. hit(s) with all data for entry = 50030986
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304804(7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304826((S)-7-(2-chlorophenoxy)-2-((R)-2-methylpiperazin-1...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  0.700nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304804(7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...)
Affinity DataKi:  0.900nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304808(4-chloro-2-(piperazin-1-yl)thieno[2,3-d]pyrimidine...)
Affinity DataKi:  1nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304801((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...)
Affinity DataEC50:  1nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304800((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataIC50: 1.90nMAssay Description:Agonist activity against human 5HT2C receptor by GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304803((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304827((S)-7-(3-fluorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304804(7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304809(4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[2,3...)
Affinity DataKi:  4nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304801((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...)
Affinity DataKi:  7nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304803((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  10nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataEC50:  10nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016970(CHEMBL608135 | CHEMBL552833 | 4-Piperazin-1-yl-thi...)
Affinity DataKi:  14nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304800((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304801((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304806((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  20nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304820(2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | C...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016972(CHEMBL595555 | CHEMBL543969 | 4-Piperazin-1-yl-fur...)
Affinity DataKi:  22nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304806((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataEC50:  22nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304812(4-methoxy-2-(piperazin-1-yl)-5,6,7,8-tetrahydroqui...)
Affinity DataKi:  23nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304823(1-(piperazin-1-yl)isoquinoline | CHEMBL595552)
Affinity DataIC50: 24nMAssay Description:Antagonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304800((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...)
Affinity DataKi:  25nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304820(2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | C...)
Affinity DataEC50:  25nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataIC50: 28nMAssay Description:Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304818(4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[3,2...)
Affinity DataKi:  28nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304806((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304820(2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | C...)
Affinity DataKi:  45nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataIC50: 46nMAssay Description:Agonist activity against human 5HT2A receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataEC50:  70nMAssay Description:Agonist activity against human 5HT2A receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304801((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...)
Affinity DataKi:  83nMAssay Description:Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataEC50:  87nMAssay Description:Agonist activity against human 5HT2A receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304815(4-(piperazin-1-yl)thieno[3,2-d]pyrimidine | CHEMBL...)
Affinity DataKi:  113nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304803((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataEC50:  120nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304825(4-(3-chlorobenzyloxy)-7-methyl-2-(piperazin-1-yl)t...)
Affinity DataIC50: 126nMAssay Description:Antagonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304810(4-(piperazin-1-yl)thieno[2,3-d]pyrimidine | CHEMBL...)
Affinity DataKi:  127nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304800((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...)
Affinity DataKi:  153nMAssay Description:Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304811(6-methyl-4-(piperazin-1-yl)furo[2,3-d]pyrimidine |...)
Affinity DataKi:  156nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016972(CHEMBL595555 | CHEMBL543969 | 4-Piperazin-1-yl-fur...)
Affinity DataEC50:  164nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016970(CHEMBL608135 | CHEMBL552833 | 4-Piperazin-1-yl-thi...)
Affinity DataEC50:  187nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
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