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Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50031006
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305149(2-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305150(3-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305157(3-chloro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305156(2-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)
Affinity DataKi:  1nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305155(3-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)
Affinity DataKi:  1nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305148(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305153(2-bromo-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}....)
Affinity DataKi:  2nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305154((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)
Affinity DataKi:  3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305152(3-chloro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)
Affinity DataKi:  4nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305151((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)
Affinity DataKi:  13nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305193(CHEMBL589387 | Methyl 9-(3-fluoro-4-hydroxyphenyl)...)
Affinity DataKi:  29nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305196(10-(2-fluoro-4-hydroxyphenyl)-9,13,15-triazatetrac...)
Affinity DataKi:  34nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305178(9-(4-methoxyphenyl)-8,12,14-triazatetracyclo[8.6.1...)
Affinity DataKi:  42nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305175(9-(2,3,6-trifluorophenyl)-8,12,14-triazatetracyclo...)
Affinity DataKi:  56nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305179(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)
Affinity DataKi:  71nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305173(9-(2,6-difluorophenyl)-8,12,14-triazatetracyclo[8....)
Affinity DataKi:  130nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305171(9-(3-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....)
Affinity DataKi:  200nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305174(9-(2,4-difluorophenyl)-8,12,14-triazatetracyclo[8....)
Affinity DataKi:  210nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305192(CHEMBL602648 | Methyl 9-(4-nitrophenyl)-8,12,14-tr...)
Affinity DataKi:  210nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305194(CHEMBL589632 | Methyl 9-(4-hydroxyphenyl)-8,12,14-...)
Affinity DataKi:  210nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305170(9-(2-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....)
Affinity DataKi:  220nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300198(5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine | CHEM...)
Affinity DataKi:  260nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305176(9-(2,3,4-trifluorophenyl)-8,12,14-triazatetracyclo...)
Affinity DataKi:  280nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305169(9-phenyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^...)
Affinity DataKi:  370nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305188(4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^{2,7}.0^{...)
Affinity DataKi:  400nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305162(CHEMBL595397 | Methyl 2-{8,12,14-triazatetracyclo[...)
Affinity DataKi:  460nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300197(4-phenyl-7H-pyrrolo[2,3-d]pyrimidine | CHEMBL57897...)
Affinity DataKi:  486nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305172(9-(4-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....)
Affinity DataKi:  490nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305195(CHEMBL602100 | Ethyl 9-(4-hydroxyphenyl)-8,12,14,1...)
Affinity DataKi:  630nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305163(8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17}]h...)
Affinity DataKi:  750nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305166(9-benzyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305177(2-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305183(9-(pyridin-4-yl)-8,12,14-triazatetracyclo[8.6.1.0^...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305187(9-(3-fluorophenyl)-8,12,14,16-tetraazatetracyclo[8...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305158(9-ethyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305165(9-[(benzyloxy)methyl]-8,12,14-triazatetracyclo[8.6...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305160(9-(propan-2-yl)-8,12,14-triazatetracyclo[8.6.1.0^{...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305180(CHEMBL604246 | N-(4-{8,12,14-triazatetracyclo[8.6....)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305161(9-tert-butyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305167(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305168(3-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305164(9-cyclohexyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305181(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305159(9-(2-methylpropyl)-8,12,14-triazatetracyclo[8.6.1....)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305197(10-(4-methoxyphenyl)-9,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305186(9-phenyl-8,12,14,16-tetraazatetracyclo[8.6.1.0^{2,...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305182(CHEMBL592269 | N-methyl-4-{8,12,14-triazatetracycl...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305189(10,20,22-triazahexacyclo[15.6.1.0^{2,10}.0^{3,8}.0...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305185(9-[(benzyloxy)methyl]-8,12,14,16-tetraazatetracycl...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305191(4-methylbenzene-1-sulfonic acid; N-{dispiro[adaman...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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