Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50031487
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataKi:  25nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314072(5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)
Affinity DataKd:  15nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  17nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivin receptor type-2B(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  92nMAssay Description:Binding affinity to ACVR2betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  160nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  780nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhosphatidylinositol 4-kinase beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to PIK4CbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCasein kinase I isoform epsilon(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  260nMAssay Description:Binding affinity to CSNK1epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  190nMAssay Description:Binding affinity to JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  170nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  19nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  16nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  120nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)