Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50031045
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305879((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305883((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305883((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305881((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305883((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  7nMAssay Description:Inhibition of P70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305881((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  12nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305880((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305883((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305881((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305883((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  64nMAssay Description:Inhibition of GSK3beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305880((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305881((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of GSK3beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305879((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305879((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of GSK3beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305881((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of GSK3beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  670nMAssay Description:Inhibition of GSK3beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305882((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305880((S)-1-(6-(furan-3-yl)-5-(3-methyl-1H-pyrazolo[4,3-...)
Affinity DataIC50:  3.86E+3nMAssay Description:Inhibition of GSK3beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50305878((2S)-1-{[6-furan-3-yl-5-(3-methyl-2H-indazol-5-yl)...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed