Compile Data Set for Download or QSAR
maximum 50k data
Found 85 Enz. Inhib. hit(s) with all data for entry = 50031258
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  1.70nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309961(CHEMBL3217125 | N-((cis)-4-aminocyclohexyl)-N-(3-c...)
Affinity DataKi:  1.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309959((exo)-1-methyl-N-(octahydrocyclopenta[c]pyrrol-5-y...)
Affinity DataKi:  2nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309958((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataKi:  2.40nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309954((exo)-1-methyl-N-(2-methyloctahydrocyclopenta[c]py...)
Affinity DataKi:  2.5nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataKi:  2.60nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataKi:  2.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309962((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  2.90nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309970((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataKi:  3.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309969((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataKi:  3.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309957((exo)-N-(3-isopropoxybenzyl)-1-methyl-N-(octahydro...)
Affinity DataKi:  4nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309968((exo)-N-(2-(2-fluoropropyl)octahydrocyclopenta[c]p...)
Affinity DataKi:  4.40nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309956((exo)-N-(3-(cyclopentyloxy)benzyl)-1-methyl-N-(oct...)
Affinity DataKi:  5.30nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  5.70nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309967((exo)-1-methyl-N-(3-(trifluoromethoxy)benzyl)-N-(2...)
Affinity DataKi:  11nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309964((endo)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-1-me...)
Affinity DataKi:  27nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataKi:  177nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309955((exo)-N-(3-(cyclopentyloxy)-4-methoxybenzyl)-1-met...)
Affinity DataKi: >641nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309959((exo)-1-methyl-N-(octahydrocyclopenta[c]pyrrol-5-y...)
Affinity DataKi:  1.65E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309962((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309969((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataKi:  2.11E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309954((exo)-1-methyl-N-(2-methyloctahydrocyclopenta[c]py...)
Affinity DataKi:  2.56E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  3.31E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309961(CHEMBL3217125 | N-((cis)-4-aminocyclohexyl)-N-(3-c...)
Affinity DataKi:  3.76E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataKi:  3.81E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataKi:  4.50E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309967((exo)-1-methyl-N-(3-(trifluoromethoxy)benzyl)-N-(2...)
Affinity DataKi:  4.53E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309964((endo)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-1-me...)
Affinity DataKi: >4.59E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309958((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataKi: >4.76E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309970((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataKi:  4.91E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309968((exo)-N-(2-(2-fluoropropyl)octahydrocyclopenta[c]p...)
Affinity DataKi: >5.19E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309967((exo)-1-methyl-N-(3-(trifluoromethoxy)benzyl)-N-(2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309965((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309969((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309961(CHEMBL3217125 | N-((cis)-4-aminocyclohexyl)-N-(3-c...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309959((exo)-1-methyl-N-(octahydrocyclopenta[c]pyrrol-5-y...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309968((exo)-N-(2-(2-fluoropropyl)octahydrocyclopenta[c]p...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of human ERG by patch clamp studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309962((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of human ERG by patch clamp studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309957((exo)-N-(3-isopropoxybenzyl)-1-methyl-N-(octahydro...)
Affinity DataIC50:  2.21E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309958((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-cy...)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309969((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309967((exo)-1-methyl-N-(3-(trifluoromethoxy)benzyl)-N-(2...)
Affinity DataIC50:  3.02E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataIC50: >3.45E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309966((exo)-N-(2-(2-hydroxy-2-phenylethyl)octahydrocyclo...)
Affinity DataIC50:  3.88E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309960((exo)-1-Methyl-1H-imidazole-4-carboxylic acid(3-tr...)
Affinity DataIC50:  4.33E+3nMAssay Description:Inhibition of human ERG by patch clamp studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309963((exo)-N-(2-ethyloctahydrocyclopenta[c]pyrrol-5-yl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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