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Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50031621
Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316351(2-(5-{[(2S)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316344(2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316346(2-(5-{[(2R)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316342(2-[5-(2-Aminoethoxy)pyridin-3-yl]-8,9-dimethoxyben...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316343(2-(5-{[(2S)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316345(2-(5-{[(2S)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316355(2-(5-{[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316359(2-(5-{[(2S)-2-Amino-3-(3,4-dichlorophenyl)propyl]o...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316349(2-(5-{[(2S)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316357(2-(5-{[(2S)-2-Amino-3-(2-chlorophenyl)propyl]oxy}p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316358(2-(5-{[(2S)-2-Amino-3-(3-chlorophenyl)propyl]oxy}p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316360(2-(5-{[(2S)-2-Amino-3-pyridin-4-ylpropyl]oxy}pyrid...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316353(2-[5-({(2S)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316347(2-(5-{[(2S)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316352(2-(5-{[(2R)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316356(2-(5-{[(2R)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316350(2-(5-{[(2R)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316348(2-(5-{[(2R)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316359(2-(5-{[(2S)-2-Amino-3-(3,4-dichlorophenyl)propyl]o...)
Affinity DataIC50:  19nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316354(2-[5-({(2R)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316351(2-(5-{[(2S)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Affinity DataIC50:  21nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target3-phosphoinositide-dependent protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM19087(15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8....)
Affinity DataIC50:  60nMAssay Description:Inhibition of human GST-tagged-PDK1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316346(2-(5-{[(2R)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Affinity DataIC50:  72nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316358(2-(5-{[(2S)-2-Amino-3-(3-chlorophenyl)propyl]oxy}p...)
Affinity DataIC50:  76nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316355(2-(5-{[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Affinity DataIC50:  77nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316358(2-(5-{[(2S)-2-Amino-3-(3-chlorophenyl)propyl]oxy}p...)
Affinity DataIC50:  78nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316342(2-[5-(2-Aminoethoxy)pyridin-3-yl]-8,9-dimethoxyben...)
Affinity DataIC50:  80nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316350(2-(5-{[(2R)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Affinity DataIC50:  88nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316352(2-(5-{[(2R)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Affinity DataIC50:  93nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316344(2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Affinity DataIC50:  97nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316357(2-(5-{[(2S)-2-Amino-3-(2-chlorophenyl)propyl]oxy}p...)
Affinity DataIC50:  106nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316349(2-(5-{[(2S)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Affinity DataIC50:  107nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316353(2-[5-({(2S)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Affinity DataIC50:  182nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316351(2-(5-{[(2S)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Affinity DataIC50:  183nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316353(2-[5-({(2S)-2-Amino-3-[3-(trifluoromethyl)phenyl]p...)
Affinity DataIC50:  209nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316345(2-(5-{[(2S)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Affinity DataIC50:  216nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316347(2-(5-{[(2S)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Affinity DataIC50:  219nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316343(2-(5-{[(2S)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Affinity DataIC50:  235nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316352(2-(5-{[(2R)-2-Amino-3-(4-fluorophenyl)propyl]oxy}p...)
Affinity DataIC50:  251nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316356(2-(5-{[(2R)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Affinity DataIC50:  254nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316350(2-(5-{[(2R)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Affinity DataIC50:  259nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316349(2-(5-{[(2S)-2-Amino-3-phenylpropyl]oxy}pyridin-3-y...)
Affinity DataIC50:  261nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316355(2-(5-{[(2S)-2-Amino-3-(1H-indol-3-yl)propyl]oxy}py...)
Affinity DataIC50:  302nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316346(2-(5-{[(2R)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Affinity DataIC50:  318nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316360(2-(5-{[(2S)-2-Amino-3-pyridin-4-ylpropyl]oxy}pyrid...)
Affinity DataIC50:  343nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316344(2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-di...)
Affinity DataIC50:  377nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316342(2-[5-(2-Aminoethoxy)pyridin-3-yl]-8,9-dimethoxyben...)
Affinity DataIC50:  402nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316345(2-(5-{[(2S)-2-Aminobutyl]oxy}pyridin-3-yl)-8,9-dim...)
Affinity DataIC50:  422nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316359(2-(5-{[(2S)-2-Amino-3-(3,4-dichlorophenyl)propyl]o...)
Affinity DataIC50:  433nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316348(2-(5-{[(2R)-2-Amino-4-methylpentyl]oxy}pyridin-3-y...)
Affinity DataIC50:  443nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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