Compile Data Set for Download or QSAR
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Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50031444
TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313480(4-(cyclohexylamino)-6-(piperazin-1-yl)-1,3,5-triaz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313474(4-cyclooctyl-6-propylpyrimidine-2-carbonitrile | C...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313467(4-(3-tert-butylphenyl)-6-propylpyrimidine-2-carbon...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313465(4-(4-chloro-3-(trifluoromethyl)phenyl)-6-propylpyr...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313461(4-propyl-6-(3-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313465(4-(4-chloro-3-(trifluoromethyl)phenyl)-6-propylpyr...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313461(4-propyl-6-(3-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313473(4-cycloheptyl-6-propylpyrimidine-2-carbonitrile | ...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313469(4-(3-(methylsulfonyl)phenyl)-6-propylpyrimidine-2-...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313472(4-(3,4-dimethylphenyl)-6-propylpyrimidine-2-carbon...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313469(4-(3-(methylsulfonyl)phenyl)-6-propylpyrimidine-2-...)
Affinity DataIC50:  148nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313468(4-(3-cyclopentylphenyl)-6-propylpyrimidine-2-carbo...)
Affinity DataIC50:  155nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313480(4-(cyclohexylamino)-6-(piperazin-1-yl)-1,3,5-triaz...)
Affinity DataIC50:  158nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataIC50:  160nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313470(4-propyl-6-m-tolylpyrimidine-2-carbonitrile | CHEM...)
Affinity DataIC50:  181nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313471(4-(3-cyanophenyl)-6-propylpyrimidine-2-carbonitril...)
Affinity DataIC50:  191nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313467(4-(3-tert-butylphenyl)-6-propylpyrimidine-2-carbon...)
Affinity DataIC50:  191nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313471(4-(3-cyanophenyl)-6-propylpyrimidine-2-carbonitril...)
Affinity DataIC50:  293nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  320nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313468(4-(3-cyclopentylphenyl)-6-propylpyrimidine-2-carbo...)
Affinity DataIC50:  457nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313480(4-(cyclohexylamino)-6-(piperazin-1-yl)-1,3,5-triaz...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313475(4-cyclohexyl-6-propylpyrimidine-2-carbonitrile | C...)
Affinity DataIC50:  680nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313462(4-phenyl-6-propylpyrimidine-2-carbonitrile | CHEMB...)
Affinity DataIC50:  985nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313464(4-propyl-6-(4-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313466(4-(2-chloro-3-(trifluoromethyl)phenyl)-6-propylpyr...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313466(4-(2-chloro-3-(trifluoromethyl)phenyl)-6-propylpyr...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313464(4-propyl-6-(4-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313470(4-propyl-6-m-tolylpyrimidine-2-carbonitrile | CHEM...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313473(4-cycloheptyl-6-propylpyrimidine-2-carbonitrile | ...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313480(4-(cyclohexylamino)-6-(piperazin-1-yl)-1,3,5-triaz...)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313474(4-cyclooctyl-6-propylpyrimidine-2-carbonitrile | C...)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313463(4-propyl-6-(2-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  6.46E+3nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  6.76E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313478(4-(3-(tert-butylamino)propyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  9.77E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313472(4-(3,4-dimethylphenyl)-6-propylpyrimidine-2-carbon...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313475(4-cyclohexyl-6-propylpyrimidine-2-carbonitrile | C...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313463(4-propyl-6-(2-(trifluoromethyl)phenyl)pyrimidine-2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313462(4-phenyl-6-propylpyrimidine-2-carbonitrile | CHEMB...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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