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Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50039126
LigandPNGBDBM50315610((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.210nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315616(3-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50:  0.230nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315608((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.630nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315609((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.830nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50273167((5-Trifluoromethylpyridin-2-yl)-[7-(3-trifluoromet...)
Affinity DataIC50:  0.850nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50272850(2-(methoxymethyl)-N-(4-(trifluoromethyl)phenyl)-7-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315612(7-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50:  1.65nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315615(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315615(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50:  3.25nMpH: 5.0Assay Description:Inhibition of rat TRPV1 at pH 5 to 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315614((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50273214(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(6-(trifluor...)
Affinity DataIC50:  7.10nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50191704((R)-2-methyl-N-(4-(trifluoromethyl)phenyl)-4-(3-(t...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315618((5-Trifluoromethylpyridin-2-yl)-[7-(3-trifluoromet...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20504(1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)py...)
Affinity DataIC50:  32nMAssay Description:Inhibition of rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315617(2-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315613(7-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50:  308nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315619((5-Trifluoromethylpyridin-2-yl)[2-(3-trifluorometh...)
Affinity DataIC50:  460nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50315611((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  665nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 3(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315615(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50:  980nMAssay Description:Inhibition of human ERK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed