Compile Data Set for Download or QSAR
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Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50031592
TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50309525(2-(5-(4-(4-fluorobenzyl)piperidine-1-carbonyl)-6-m...)
Affinity DataIC50:  10nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  110nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315875((S)-N-ethyl-N-(2-(1-phenylethylamino)pyridin-4-yl)...)
Affinity DataIC50:  313nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315867((S)-N-(4-fluorobenzyl)-N-(2-(1-phenylethylamino)py...)
Affinity DataIC50:  345nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315874((S)-N-(4-fluorobenzyl)-N-(2-(1-phenylethylamino)py...)
Affinity DataIC50:  408nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315873((S)-N-(4-fluorobenzyl)-N-(2-(1-phenylethylamino)py...)
Affinity DataIC50:  589nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315872(CHEMBL1092953 | N-(4-fluorobenzyl)-N-(2-(isopropyl...)
Affinity DataIC50:  671nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315877(CHEMBL1090584 | N-(4-fluorobenzyl)-N-(2-((S)-1-phe...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315871(CHEMBL1091265 | N-(2-(cyclohexylamino)pyridin-4-yl...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315869(CHEMBL1092962 | N-(2-(benzylamino)pyridin-4-yl)-N-...)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315866(CHEMBL1091737 | N-(4-fluorobenzyl)-N-(pyridin-4-yl...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315870(CHEMBL1092963 | N-(2-aminopyridin-4-yl)-N-(4-fluor...)
Affinity DataIC50:  5.08E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315876((S)-N-(4-fluorobenzyl)-N-(2-(1-phenylethylamino)py...)
Affinity DataIC50:  7.54E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Scios

Curated by ChEMBL
LigandPNGBDBM50315868((R)-N-(4-fluorobenzyl)-N-(2-(1-phenylethylamino)py...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of p38alpha assessed as inhibition of gamma-32p-ATP incorporation into biotin peptide substrate after 60 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed