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Found 37 Enz. Inhib. hit(s) with all data for entry = 50031698
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317487((S)-2-((4-(4-(thiophen-3-yl)phenoxy)phenoxy)methyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317483((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317488((R)-4-(2-((4-(4-(thiophen-3-yl)benzyl)phenoxy)meth...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317482((S)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317496((R)-2-((4-(biphenyl-4-yloxy)phenoxy)methyl)piperid...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317479((S)-2-((4-(4-chlorophenoxy)phenoxy)methyl)piperidi...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317497((S)-2-((4-(biphenyl-4-yloxy)phenoxy)methyl)piperid...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317495((S)-2-((4-phenoxyphenoxy)methyl)piperidine | CHEMB...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317494((R)-2-((4-phenoxyphenoxy)methyl)piperidine | CHEMB...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317488((R)-4-(2-((4-(4-(thiophen-3-yl)benzyl)phenoxy)meth...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317483((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317485((S)-2-((4-(4-(thiophen-2-yl)benzyl)phenoxy)methyl)...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317493((R)-2-((4-benzylphenoxy)methyl)piperidine | CHEMBL...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317486((S)-2-((4-(4-(thiophen-3-yl)benzyl)phenoxy)methyl)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317492((R/S)-2-((4-phenoxyphenoxy)methyl)piperidine | CHE...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317499((S)-2-((4-(4-fluorophenoxy)phenoxy)methyl)piperidi...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317487((S)-2-((4-(4-(thiophen-3-yl)phenoxy)phenoxy)methyl...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317498((R)-2-((4-(4-(trifluoromethyl)phenoxy)phenoxy)meth...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317493((R)-2-((4-benzylphenoxy)methyl)piperidine | CHEMBL...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317496((R)-2-((4-(biphenyl-4-yloxy)phenoxy)methyl)piperid...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317491((R/S)-2-((4-benzylphenoxy)methyl)piperidine | CHEM...)
Affinity DataIC50:  105nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317482((S)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317479((S)-2-((4-(4-chlorophenoxy)phenoxy)methyl)piperidi...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317497((S)-2-((4-(biphenyl-4-yloxy)phenoxy)methyl)piperid...)
Affinity DataIC50:  114nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317494((R)-2-((4-phenoxyphenoxy)methyl)piperidine | CHEMB...)
Affinity DataIC50:  126nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317491((R/S)-2-((4-benzylphenoxy)methyl)piperidine | CHEM...)
Affinity DataIC50:  134nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317498((R)-2-((4-(4-(trifluoromethyl)phenoxy)phenoxy)meth...)
Affinity DataIC50:  173nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317499((S)-2-((4-(4-fluorophenoxy)phenoxy)methyl)piperidi...)
Affinity DataIC50:  174nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317492((R/S)-2-((4-phenoxyphenoxy)methyl)piperidine | CHE...)
Affinity DataIC50:  207nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317481((S)-3-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)
Affinity DataIC50:  212nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317495((S)-2-((4-phenoxyphenoxy)methyl)piperidine | CHEMB...)
Affinity DataIC50:  286nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317500((R)-2-((4-(4-chlorobenzyl)phenoxy)methyl)piperidin...)
Affinity DataIC50:  315nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317490((R/S)-2-((4-benzylphenoxy)methyl)piperazine | CHEM...)
Affinity DataIC50:  342nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317501((S)-2-((4-(4-chlorobenzyl)phenoxy)methyl)piperidin...)
Affinity DataIC50:  438nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317489((R/S)-1-benzyl-3-((4-benzylphenoxy)methyl)piperazi...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317480((S)-2-(2-((4-(4-chlorophenoxy)phenoxy)methyl)piper...)
Affinity DataIC50:  880nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317484((S)-3-((2-((4-(4-chlorophenoxy)phenoxy)methyl)pipe...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed