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Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50031713
TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317751(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  7nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317749(2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317756(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317765(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317759(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317748(2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317758(2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317757(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  18nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317755(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  21nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317764(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317752(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  24nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317754(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  34nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317763(3-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  55nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317762(3-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  69nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317766(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  120nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317753(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  190nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317761(4-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  270nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity nerve growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50:  350nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317760(4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of GST-tagged human recombinant c-met N terminal domain expressed in Hi5 insect cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of LcKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHigh affinity immunoglobulin gamma Fc receptor I(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin receptor(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50317750(2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoroph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed