Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50031748
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(CHEMBL1097751 | tert-Butyl (4R)-4-(2-Chloro-4-fluo...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318296((R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318296((R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318297(CHEMBL1094169 | Methyl (4R)-(2-Chloro-4-fluorophen...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50:  46nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(CHEMBL1097751 | tert-Butyl (4R)-4-(2-Chloro-4-fluo...)
Affinity DataIC50:  59nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318299(CHEMBL1097753 | Methyl (4R)-5-Cyano-2,6-dimethyl-4...)
Affinity DataIC50:  77nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50:  126nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318300(CHEMBL1095097 | EPLERENONE | SC-66110)
Affinity DataIC50:  135nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(CHEMBL1097751 | tert-Butyl (4R)-4-(2-Chloro-4-fluo...)
Affinity DataIC50:  246nMAssay Description:Inhibition of androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318296((R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50:  270nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318301(CHEMBL1094798 | Methyl (4R)-2-(Chloromethyl)-5-cya...)
Affinity DataIC50:  340nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318302(CHEMBL1097752 | Methyl (4S)-5-Cyano-2,6-dimethyl-4...)
Affinity DataIC50:  469nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318303((-)-(S)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50:  536nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318296((R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50:  730nMAssay Description:Inhibition of androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50:  768nMAssay Description:Inhibition of progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50:  1.27E+3nMAssay Description:Inhibition of androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318296((R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(CHEMBL1097751 | tert-Butyl (4R)-4-(2-Chloro-4-fluo...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318304(CHEMBL1094801 | Methyl (4S)-(2-Chloro-4-fluorophen...)
Affinity DataIC50:  2.20E+3nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318305(CHEMBL1096306 | Methyl (4S)-2-(Chloromethyl)-5-cya...)
Affinity DataIC50:  2.80E+3nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318306((S)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50:  3.28E+3nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(CHEMBL1097751 | tert-Butyl (4R)-4-(2-Chloro-4-fluo...)
Affinity DataIC50:  3.52E+3nMAssay Description:Inhibition of progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318307(CHEMBL1097750 | tert-Butyl (4S)-4-(2-Chloro-4-fluo...)
Affinity DataIC50:  3.52E+3nMAssay Description:Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318296((R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318295(CHEMBL1097751 | tert-Butyl (4R)-4-(2-Chloro-4-fluo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed