Compile Data Set for Download or QSAR
maximum 50k data
Found 17 Enz. Inhib. hit(s) with all data for entry = 50031750
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318372((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318382(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318375((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-3-fl...)
Affinity DataKi:  4.01nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50198702((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318381((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-f...)
Affinity DataKi:  5.42nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318380((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(2-f...)
Affinity DataKi:  8.41nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318374((E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-6-fl...)
Affinity DataKi:  9.15nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318383((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  26.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318376((Z)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-6-fl...)
Affinity DataKi:  44.0nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318373((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Affinity DataKi:  46.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318377((Z)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Affinity DataKi:  49.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318371((E)-3-(pyridin-4-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  54.8nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318379((E)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Affinity DataKi:  56.1nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318378((E)-2-fluoro-4-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Affinity DataKi:  73.4nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318370((E)-3-(pyridin-3-ylethynyl)cyclohex-2-enone O-meth...)
Affinity DataKi:  252nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318382(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Affinity DataKd:  13.7nMAssay Description:Binding affinity to mGluR5 ligand binding site 2 in Sprague-Dawley rat brain P2 membrane after 45 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50318382(3-[pyridine-2-yl)ethynyl]cyclohex-2-enone-O-fluoro...)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to mGluR5 ligand binding site 1 in Sprague-Dawley rat brain P2 membrane after 45 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed