Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50031803
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319612((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319613((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248594(4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319614(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319613((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...)
Affinity DataIC50: 174nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248594(4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...)
Affinity DataIC50: 184nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319612((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...)
Affinity DataIC50: 316nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319614(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Affinity DataIC50: 488nMAssay Description:Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 4.40E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319613((R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopy...)
Affinity DataIC50: 4.82E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50248594(4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonit...)
Affinity DataIC50: 6.95E+3nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319612((R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to estrogen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319611((R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-ylo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319614(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to progesterone receptor by PRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed