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Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50032022
Target5-hydroxytryptamine receptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  15nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi:  76nMAssay Description:Binding affinity to adrenergic Alpha-1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  103nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  180nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to adrenergic alpha-1b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-2 adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to beta2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(4) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(4) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-1 adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249488(4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323411(1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323406(1-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)met...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323405(1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249488(4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323411(1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)me...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50184796(1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...)
Affinity DataIC50:  78nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50184796(1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...)
Affinity DataIC50:  96nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323410(1-(4-methoxyphenyl)-4-((5-methyl-1-phenyl-1H-pyraz...)
Affinity DataIC50:  105nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataIC50:  124nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323410(1-(4-methoxyphenyl)-4-((5-methyl-1-phenyl-1H-pyraz...)
Affinity DataIC50:  126nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataIC50:  216nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323409(1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-(3...)
Affinity DataIC50:  328nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323409(1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-(3...)
Affinity DataIC50:  333nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323405(1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...)
Affinity DataIC50:  823nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323404(1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...)
Affinity DataIC50:  1.69E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323406(1-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)met...)
Affinity DataIC50:  1.86E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323403(1-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl)-...)
Affinity DataIC50:  1.87E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323404(1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323408(1-(4-fluorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazo...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323408(1-(4-fluorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazo...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323407(1-(4-methoxyphenyl)-4-((3-methyl-1-phenyl-1H-pyraz...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323403(1-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl)-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSmoothened homolog(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323407(1-(4-methoxyphenyl)-4-((3-methyl-1-phenyl-1H-pyraz...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed