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Found 46 Enz. Inhib. hit(s) with all data for entry = 50032032
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323549(CHEMBL1209434 | N-(4-styrylpyrimidin-2-yl)methanes...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323550(2-methyl-4-styrylpyrimidine | CHEMBL1209435)
Affinity DataEC50:  6.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323551(2-phenyl-4-styrylpyrimidine | CHEMBL1209436)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323552(4-styrylpyrimidine-2-thiol | CHEMBL1209437)
Affinity DataEC50:  7.80E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323553(4-methyl-6-styrylpyrimidin-2-amine | CHEMBL1209438)
Affinity DataEC50:  800nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323554(5-methyl-4-styrylpyrimidin-2-amine | CHEMBL1209514)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323555(4,5-dimethyl-6-styrylpyrimidin-2-amine | CHEMBL120...)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323556(6-styrylpyrimidine-2,4-diamine | CHEMBL1209516)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323557(2-amino-6-styrylpyrimidin-4-ol | CHEMBL1209517)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323558(4-methoxy-6-styrylpyrimidin-2-amine | CHEMBL120951...)
Affinity DataEC50:  2.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323559(4-styryl-6-(trifluoromethyl)pyrimidin-2-amine | CH...)
Affinity DataEC50:  600nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323560(5-chloro-4-styrylpyrimidin-2-amine | CHEMBL1209520)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323561(5-bromo-4-styrylpyrimidin-2-amine | CHEMBL1209521)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323562(6-styrylpyridin-2-amine | CHEMBL1209588)
Affinity DataEC50:  5.80E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323563(6-styrylpyrazin-2-amine | CHEMBL1209589)
Affinity DataEC50:  1.58E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323564(4-phenethylpyrimidin-2-amine | CHEMBL1209590)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323565(4-(phenylethynyl)pyrimidin-2-amine | CHEMBL1209591)
Affinity DataEC50:  2.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323566(5-((1R,2R)-2-phenylcyclopropyl)pyrimidin-2-amine |...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323567(4-(benzofuran-2-yl)pyrimidin-2-amine | CHEMBL12095...)
Affinity DataEC50:  4.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323568(4-(benzo[b]thiophen-2-yl)pyrimidin-2-amine | CHEMB...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323569(4-(naphthalen-2-yl)pyrimidin-2-amine | CHEMBL12095...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323570(4-(2-fluorostyryl)pyrimidin-2-amine | CHEMBL120880...)
Affinity DataEC50:  2.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323571(4-(3-fluorostyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50:  4.50E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323572(4-(4-fluorostyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50:  4.50E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323573(2-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323574(3-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323575(4-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323576(4-(2-methylstyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323577(4-(3-methylstyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323578(4-(4-methylstyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323579(4-(2-(thiophen-2-yl)vinyl)pyrimidin-2-amine | CHEM...)
Affinity DataEC50:  4.10E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323580(4-(2-(furan-2-yl)vinyl)pyrimidin-2-amine | CHEMBL1...)
Affinity DataEC50:  9.40E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323581(4-(2-(pyridin-2-yl)vinyl)pyrimidin-2-amine | CHEMB...)
Affinity DataEC50:  1.17E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323582(4-(2-(pyridin-3-yl)vinyl)pyrimidin-2-amine | CHEMB...)
Affinity DataEC50:  1.64E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323583(4-(2-(pyridin-4-yl)vinyl)pyrimidin-2-amine | CHEMB...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323584(CHEMBL1209746 | ethyl 2-oxo-2-(4-styrylpyrimidin-2...)
Affinity DataEC50:  5.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGluR4 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mGluR5 expressed in CHO-K1 cells in absence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of rat mGluR4 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323548(CHEMBL1209433 | N,N-dimethyl-4-styrylpyrimidin-2-a...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323547(CHEMBL1209432 | N-methyl-4-styrylpyrimidin-2-amine)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed