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Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50032194
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325819((Z)-5-((2'-(trifluoromethoxy)biphenyl-3-yl)methyle...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human Nav1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141073((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...)
Affinity DataKi:  360nMAssay Description:Binding affinity to human Nav1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  15nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: <50nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: <50nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50:  50nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: <50nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50:  150nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  230nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50:  260nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325817(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50:  270nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325812(5-methyl-4-(2'-(trifluoromethoxy)biphenyl-3-yl)thi...)
Affinity DataIC50:  430nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325808(4-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-1-...)
Affinity DataIC50:  490nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325813(2-(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazol-2...)
Affinity DataIC50:  620nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325816(2-(1H-imidazol-2-yl)-4-(2'-(trifluoromethoxy)biphe...)
Affinity DataIC50:  950nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325807(1-methyl-4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-...)
Affinity DataIC50:  1.25E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325815(2-(pyrazin-2-yl)-4-(2'-(trifluoromethoxy)biphenyl-...)
Affinity DataIC50:  1.26E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325811(CHEMBL1224725 | N,N-dimethyl-4-(2'-(trifluorometho...)
Affinity DataIC50:  1.37E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325814((4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazol-2-y...)
Affinity DataIC50:  1.80E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325802(4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazole | CH...)
Affinity DataIC50:  1.94E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50:  2.10E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325803(2-methyl-4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxa...)
Affinity DataIC50:  2.14E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325809(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole | C...)
Affinity DataIC50:  2.16E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325804(4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazole-2-ca...)
Affinity DataIC50:  2.36E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325806(5-chloro-4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-...)
Affinity DataIC50:  2.77E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325810(2-methyl-4-(2'-(trifluoromethoxy)biphenyl-3-yl)thi...)
Affinity DataIC50:  2.99E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325801(4-(2'-(trifluoromethyl)biphenyl-3-yl)oxazole | CHE...)
Affinity DataIC50:  5.31E+3nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50:  8.79E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325817(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325817(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325817(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed