Compile Data Set for Download or QSAR
Report error Found 145 Enz. Inhib. hit(s) with all data for entry = 50039297
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18207BDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataIC50: 0.510nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326943BDBM50326943((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326945BDBM50326945((R)-2-((1H-pyrrolo[3,2-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326932BDBM50326932(2-((1H-pyrrolo[3,2-b]pyridin-1-yl)methyl)-1,1,1-tr...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326945BDBM50326945((R)-2-((1H-pyrrolo[3,2-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 2nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326946BDBM50326946(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326947BDBM50326947(1,1,1-Trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-...)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326932BDBM50326932(2-((1H-pyrrolo[3,2-b]pyridin-1-yl)methyl)-1,1,1-tr...)
Affinity DataIC50: 2.80nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326948BDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50: 3nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326946BDBM50326946(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50: 3.30nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18207BDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataIC50: 3.40nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326933BDBM50326933(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 4.40nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326949BDBM50326949(4-(2,3-Dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-m...)
Affinity DataIC50: 4.5nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326948BDBM50326948(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326943BDBM50326943((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 6nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326950BDBM50326950(2-(4-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5...)
Affinity DataIC50: 6.60nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19190BDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 6.60nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326934BDBM50326934(2-((1H-indol-2-yl)methyl)-1,1,1-trifluoro-4-(5-flu...)
Affinity DataIC50: 6.60nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326957BDBM50326957(4-(5-Chloro-2,3-dihydrobenzofuran-7-yl)-1,1,1-trif...)
Affinity DataIC50: 7nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326935BDBM50326935(1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 7.10nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326936BDBM50326936(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 7.30nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326953BDBM50326953(1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326954BDBM50326954(1,1,1-Trifluoro-4-(2-methoxy-5-pyridin-3-ylphenyl)...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326952BDBM50326952((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 8nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326936BDBM50326936(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 8.20nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326955BDBM50326955(1,1,1-Trifluoro-4-methyl-4-phenyl-2-(1H-pyrrolo[2,...)
Affinity DataIC50: 9.30nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326947BDBM50326947(1,1,1-Trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-...)
Affinity DataIC50: 9.30nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326933BDBM50326933(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 9.80nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326943BDBM50326943((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataEC50:  10nMAssay Description:Transactivation activity at glucocorticoid receptor in HFF assessed as induction of aromatase activity after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326956BDBM50326956(1,1,1-Trifluoro-4-(5-fluoro-2-methylphenyl)-4-meth...)
Affinity DataIC50: 10nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326958BDBM50326958(3-[4,4,4-Trifluoro-3-hydroxy-1,1-dimethyl-3-(1H-py...)
Affinity DataIC50: 11nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326959BDBM50326959(1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...)
Affinity DataIC50: 12nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19190BDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 15nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326958BDBM50326958(3-[4,4,4-Trifluoro-3-hydroxy-1,1-dimethyl-3-(1H-py...)
Affinity DataIC50: 15nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326949BDBM50326949(4-(2,3-Dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-m...)
Affinity DataIC50: 15nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326957BDBM50326957(4-(5-Chloro-2,3-dihydrobenzofuran-7-yl)-1,1,1-trif...)
Affinity DataIC50: 17nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326951BDBM50326951(4-Pyrimidin-5-yl-2-[4,4,4-trifluoro-3-hydroxy-1,1-...)
Affinity DataIC50: 19nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326952BDBM50326952((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 20nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326943BDBM50326943((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 20nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326951BDBM50326951(4-Pyrimidin-5-yl-2-[4,4,4-trifluoro-3-hydroxy-1,1-...)
Affinity DataIC50: 21nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326934BDBM50326934(2-((1H-indol-2-yl)methyl)-1,1,1-trifluoro-4-(5-flu...)
Affinity DataIC50: 21nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326937BDBM50326937(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 21nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326938BDBM50326938(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-2-fur...)
Affinity DataIC50: 22nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326945BDBM50326945((R)-2-((1H-pyrrolo[3,2-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 22nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326953BDBM50326953(1,1,1-Trifluoro-4-(3-fluorophenyl)-4-methyl-2-(1H-...)
Affinity DataIC50: 23nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326950BDBM50326950(2-(4-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5...)
Affinity DataIC50: 23nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326939BDBM50326939(1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-met...)
Affinity DataIC50: 23nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326952BDBM50326952((R)-2-((1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-1,1,...)
Affinity DataIC50: 27nMAssay Description:Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326946BDBM50326946(4-Fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dime...)
Affinity DataEC50:  30nMAssay Description:Transactivation activity at glucocorticoid receptor in HFF assessed as induction of aromatase activity after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326954BDBM50326954(1,1,1-Trifluoro-4-(2-methoxy-5-pyridin-3-ylphenyl)...)
Affinity DataIC50: 30nMAssay Description:Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
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