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Found 17 Enz. Inhib. hit(s) with all data for entry = 50032461
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50261110(CHEMBL493982 | Ethyl [(3aR,4aR,8aR,9aS)-9(S)-[(E)-...)
Affinity DataKi:  8nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329617(CHEMBL1270636 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  12nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329616(CHEMBL1270537 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  15nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(CHEMBL1270738 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  19nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329621(CHEMBL1271045 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-...)
Affinity DataKi:  42nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329624(CHEMBL1271353 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  49nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329625(CHEMBL1271461 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  61nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329626(CHEMBL1269815 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-...)
Affinity DataKi:  75nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329622(CHEMBL1271149 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-...)
Affinity DataKi:  144nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329619(CHEMBL1270840 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  240nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329620(CHEMBL1270942 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataKi:  250nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329623(CHEMBL1271252 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-1-...)
Affinity DataKi:  337nMAssay Description:Displacement of high affinity TRAP form human platelet PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(CHEMBL1270738 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of PAR1-mediated aggregation of TRAP-stimulated human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(CHEMBL1270738 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(CHEMBL1270738 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(CHEMBL1270738 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329618(CHEMBL1270738 | ethyl(1R,3aR,4aR,6R,8aR,9S,9aS)-9-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed