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Found 153 Enz. Inhib. hit(s) with all data for entry = 50032641
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332490(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332485(CHEMBL1630112 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(CHEMBL1630111 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332490(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332489(CHEMBL1630116 | N-(2-aminophenyl)-3-(4-(4-(3-chlor...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332485(CHEMBL1630112 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332484(CHEMBL1630111 | N-(2-aminophenyl)-5-(4-(3-chloro-4...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332486(CHEMBL1630113 | N-(2-aminophenyl)-3-(5-(4-(3-chlor...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  11nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332487((E)-N-(2-aminophenyl)-3-(3-(4-(3-chloro-4-(3-fluor...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332488((E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluor...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332489(CHEMBL1630116 | N-(2-aminophenyl)-3-(4-(4-(3-chlor...)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  18nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  18nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  18nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332486(CHEMBL1630113 | N-(2-aminophenyl)-3-(5-(4-(3-chlor...)
Affinity DataIC50:  26nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332488((E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluor...)
Affinity DataIC50:  29nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50: <32nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50: <32nMAssay Description:Inhibition of EGF-induced EGFR phopshorylation in human CAL27 cells overexpressing EGFR after 16 hrs by Western blotMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332487((E)-N-(2-aminophenyl)-3-(3-(4-(3-chloro-4-(3-fluor...)
Affinity DataIC50:  49nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  66nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256975((4-(2-aminophenylcarbamoyl)benzylamino)methyl nico...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  440nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  440nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332490(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  460nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332493(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)qu...)
Affinity DataIC50:  560nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332483(3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50256975((4-(2-aminophenylcarbamoyl)benzylamino)methyl nico...)
Affinity DataIC50:  620nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332494((E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332487((E)-N-(2-aminophenyl)-3-(3-(4-(3-chloro-4-(3-fluor...)
Affinity DataIC50:  850nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332492((E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  850nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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