Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50032748
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334105BDBM50334105((4-methoxy-3-(phenylethynyl)phenyl)(4-(5-methylpyr...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334106BDBM50334106((3-((3-chlorophenyl)ethynyl)-4-methoxyphenyl)(4-(p...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334110BDBM50334110((4-methoxy-3-(thiazol-2-ylethynyl)phenyl)(4-(pyrid...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334109BDBM50334109((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(pyrid...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334113BDBM50334113((4-methoxy-3-((6-methylpyridin-2-yl)ethynyl)phenyl...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334107BDBM50334107((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyridin-2-y...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334108BDBM50334108((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(5-met...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334109BDBM50334109((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(pyrid...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334110BDBM50334110((4-methoxy-3-(thiazol-2-ylethynyl)phenyl)(4-(pyrid...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334111BDBM50334111((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyrazin-2-y...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334112BDBM50334112((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(pyrim...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334108BDBM50334108((4-methoxy-3-(pyridin-2-ylethynyl)phenyl)(4-(5-met...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334113BDBM50334113((4-methoxy-3-((6-methylpyridin-2-yl)ethynyl)phenyl...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334107BDBM50334107((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyridin-2-y...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334105BDBM50334105((4-methoxy-3-(phenylethynyl)phenyl)(4-(5-methylpyr...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334115BDBM50334115((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyrimidin-4...)
Affinity DataIC50: 46nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334114BDBM50334114((4-methyl-3-(phenylethynyl)phenyl)(4-(pyridin-2-yl...)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334115BDBM50334115((4-methoxy-3-(phenylethynyl)phenyl)(4-(pyrimidin-4...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334116BDBM50334116((4-(5-methylpyridin-2-yl)piperazin-1-yl)(3-(phenyl...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334106BDBM50334106((3-((3-chlorophenyl)ethynyl)-4-methoxyphenyl)(4-(p...)
Affinity DataIC50: 66nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334117BDBM50334117((4-(pyridin-2-yl)piperazin-1-yl)(3-(pyridin-2-ylet...)
Affinity DataKi:  96nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334118BDBM50334118((3-(phenylethynyl)phenyl)(4-(pyridin-2-yl)piperazi...)
Affinity DataKi:  139nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334119BDBM50334119((3-(3-phenylprop-1-ynyl)phenyl)(4-(pyridin-2-yl)pi...)
Affinity DataKi:  139nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334120BDBM50334120((4-methyl-3-(phenylethynyl)phenyl)(4-(pyrazin-2-yl...)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334119BDBM50334119((3-(3-phenylprop-1-ynyl)phenyl)(4-(pyridin-2-yl)pi...)
Affinity DataIC50: 163nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334117BDBM50334117((4-(pyridin-2-yl)piperazin-1-yl)(3-(pyridin-2-ylet...)
Affinity DataIC50: 172nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334116BDBM50334116((4-(5-methylpyridin-2-yl)piperazin-1-yl)(3-(phenyl...)
Affinity DataIC50: 181nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334120BDBM50334120((4-methyl-3-(phenylethynyl)phenyl)(4-(pyrazin-2-yl...)
Affinity DataIC50: 192nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334121BDBM50334121((3-((3-methoxyphenyl)ethynyl)phenyl)(4-(pyridin-2-...)
Affinity DataKi:  212nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334122BDBM50334122((3-(phenylethynyl)phenyl)(4-(pyrazin-2-yl)piperazi...)
Affinity DataKi:  401nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334123BDBM50334123((3-((3-aminophenyl)ethynyl)phenyl)(4-(pyridin-2-yl...)
Affinity DataKi:  430nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334124BDBM50334124((3-(phenylethynyl)phenyl)(4-(pyrimidin-4-yl)pipera...)
Affinity DataKi:  451nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334118BDBM50334118((3-(phenylethynyl)phenyl)(4-(pyridin-2-yl)piperazi...)
Affinity DataIC50: 926nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334122BDBM50334122((3-(phenylethynyl)phenyl)(4-(pyrazin-2-yl)piperazi...)
Affinity DataIC50: 1.38E+3nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334125BDBM50334125((4-(pyridin-2-yl)piperazin-1-yl)(3-(p-tolylethynyl...)
Affinity DataKi:  1.91E+3nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334126BDBM50334126((3-((4-methoxyphenyl)ethynyl)phenyl)(4-(pyridin-2-...)
Affinity DataKi:  2.36E+3nMAssay Description:Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334121BDBM50334121((3-((3-methoxyphenyl)ethynyl)phenyl)(4-(pyridin-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334123BDBM50334123((3-((3-aminophenyl)ethynyl)phenyl)(4-(pyridin-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed