Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50033280
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342721BDBM50342721(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342728BDBM50342728(N1-(3-(2,6-dichloro-4-ethoxyphenyl)-2,5-dimethylpy...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Rat)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342721BDBM50342721(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342726BDBM50342726(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342724BDBM50342724(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342729BDBM50342729(N1-(3-(2,6-dichlorophenyl)-2,5-dimethylpyrazolo[1,...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342721BDBM50342721(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342727BDBM50342727(N1-(3-(2,6-dichloro-4-propoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342728BDBM50342728(N1-(3-(2,6-dichloro-4-ethoxyphenyl)-2,5-dimethylpy...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342731BDBM50342731(N1-cyclopentyl-N2-(3-mesityl-2,5-dimethylpyrazolo[...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342723BDBM50342723(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342732BDBM50342732(N1-(3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidin...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342730BDBM50342730(N1-cyclopentyl-N2-(3-(2,6-dichlorophenyl)-2,5-dime...)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342725BDBM50342725(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  141nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342727BDBM50342727(N1-(3-(2,6-dichloro-4-propoxyphenyl)-2,5-dimethylp...)
Affinity DataIC50: 207nMAssay Description:Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342722BDBM50342722(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataKi:  383nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342733BDBM50342733(N1-(3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidin...)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50342734BDBM50342734(N-(2-Aminoethyl)-N-ethyl-9-mesityl-2-methyl-9H-pyr...)
Affinity DataKi:  4.47E+3nMAssay Description:Binding affinity to CRHRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342721BDBM50342721(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human NPY Y2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342721BDBM50342721(N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylp...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human NPY Y5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50342733BDBM50342733(N1-(3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidin...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to CRHRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed