Compile Data Set for Download or QSAR
maximum 50k data
Found 18 Enz. Inhib. hit(s) with all data for entry = 50033007
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337934((R)-3-(2,3-dihydroxypropoxy)-6-fluoro-5-(2-fluoro-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337929((S)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337926((R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337933(3-(1,3-dihydroxypropan-2-yl)-6-fluoro-5-(2-fluoro-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM1711(CHEMBL1684067 | US8470837, 8)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337932(5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337920((R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophen...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337928((R)-3-(2,3-dihydroxypropyl)-5-(4-ethynyl-2-fluorop...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337937(5-(2-fluoro-4-iodophenylamino)-3-(3-hydroxypropyl)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM1714(CHEMBL1684071 | US8470837, 13)
Affinity DataIC50:  5nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337924((R)-6-chloro-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM1710(CHEMBL1684064 | US8470837, 5)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM1716(CHEMBL1684072 | US8470837, 17)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM1665(CHEMBL1684061 | US8470837, 2)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337927((R)-5-(4-bromo-2-fluorophenylamino)-3-(2,3-dihydro...)
Affinity DataIC50:  16nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337935(5-(2-fluoro-4-iodophenylamino)-3,8-dimethylpyrido[...)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337922((S)-3-(2,4-dihydroxybutyl)-5-(2-fluoro-4-iodopheny...)
Affinity DataIC50:  53nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50337923(3-(2-(dimethylamino)ethyl)-5-(2-fluoro-4-iodopheny...)
Affinity DataIC50:  740nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed