Compile Data Set for Download or QSAR
maximum 50k data
Found 5 Enz. Inhib. hit(s) with all data for entry = 50033011
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338038(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in presence of ATPMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338038(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in presence of ATPMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338038(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-h...)
Affinity DataKd:  8.70nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in absence of ATPMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
Affinity DataKd:  31nMAssay Description:Binding affinity to MEK1 by surface plasmon resonance in absence of ATPMore data for this Ligand-Target Pair