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Found 8 Enz. Inhib. hit(s) with all data for entry = 50033316
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ram seminal vesicle COX-1 assessed as PGE2 production from arachidonic acid after 20 mins enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM50193718(2-(2,4-dihydroxy-phenyl)-5-hydroxy-8,8-dimethyl-3-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of ram seminal vesicle COX-1 assessed as PGE2 production from arachidonic acid after 20 mins enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant COX-2 assessed as PGE2 production from arachidonic acid after 20 mins enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM50193718(2-(2,4-dihydroxy-phenyl)-5-hydroxy-8,8-dimethyl-3-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant COX-2 assessed as PGE2 production from arachidonic acid after 20 mins enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM50242014(CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of 12-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM50242014(CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of 5-LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM50242014(CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human recombinant COX-2 assessed as PGE2 production from arachidonic acid after 20 mins enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Veterinary And Pharmaceutical Sciences Brno

Curated by ChEMBL
LigandPNGBDBM50242014(CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of ram seminal vesicle COX-1 assessed as PGE2 production from arachidonic acid after 20 mins enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed